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Dual Inhibition of Topoisomerase II and Tyrosine Kinases by the Novel Bis-Fluoroquinolone Chalcone-Like Derivative HMNE3 in Human Pancreatic Cancer Cells

Both tyrosine kinase and topoisomerase II (TopII) are important anticancer targets, and their respective inhibitors are widely used in cancer therapy. However, some combinations of anticancer drugs could exhibit mutually antagonistic actions and drug resistance, which further limit their therapeutic...

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Detalles Bibliográficos
Autores principales:	Ma, Yong-Chao, Wang, Zhi-Xin, Jin, Shao-Ju, Zhang, Yan-Xin, Hu, Guo-Qiang, Cui, Dong-Tao, Wang, Jiang-Shuan, Wang, Min, Wang, Fu-Qing, Zhao, Zhi-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070812/ https://www.ncbi.nlm.nih.gov/pubmed/27760157 http://dx.doi.org/10.1371/journal.pone.0162821

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