Family Based Whole Exome Sequencing Reveals the Multifaceted Role of Notch Signaling in Congenital Heart Disease

Left-ventricular outflow tract obstructions (LVOTO) encompass a wide spectrum of phenotypically heterogeneous heart malformations which frequently cluster in families. We performed family based whole-exome and targeted re-sequencing on 182 individuals from 51 families with multiple affected members....

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Detalles Bibliográficos
Autores principales: Preuss, Christoph, Capredon, Melanie, Wünnemann, Florian, Chetaille, Philippe, Prince, Andrea, Godard, Beatrice, Leclerc, Severine, Sobreira, Nara, Ling, Hua, Awadalla, Philip, Thibeault, Maryse, Khairy, Paul, Samuels, Mark E., Andelfinger, Gregor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070860/
https://www.ncbi.nlm.nih.gov/pubmed/27760138
http://dx.doi.org/10.1371/journal.pgen.1006335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070860/
https://www.ncbi.nlm.nih.gov/pubmed/27760138
http://dx.doi.org/10.1371/journal.pgen.1006335

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