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Pancytopenia and Severe Gastrointestinal Toxicities Associated with 5-Fluorouracil in a Patient with Thymidylate Synthase (TYMS) Polymorphism

5-Fluorouracil (5-FU) is one of the most commonly used chemotherapeutic agents in solid tumors, including colon, gastric and breast cancers. The pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency leading to severe toxicity after administration of 5-flourouracil (5-FU) and c...

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Detalles Bibliográficos
Autores principales:	Wang, Bo, Walsh, Shannon J, Saif, Muhammad W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cureus 2016
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071174/ https://www.ncbi.nlm.nih.gov/pubmed/27774364 http://dx.doi.org/10.7759/cureus.798

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