Management of muscle invasive, locally advanced and metastatic urothelial carcinoma of the bladder: a literature review with emphasis on the role of surgery

Locally advanced (T3b, T4 and N1−N3) and metastatic urothelial bladder cancer (BCa) is a lethal disease with poor survival outcomes. Combination chemotherapy remains the treatment of choice in patients with metastatic disease and an important part of treatment in addition to radical cystectomy (RC)...

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Detalles Bibliográficos
Autores principales: Abufaraj, Mohammad, Gust, Kilian, Moschini, Marco, Foerster, Beat, Soria, Francesco, Mathieu, Romain, Shariat, Shahrokh F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071186/
https://www.ncbi.nlm.nih.gov/pubmed/27785430
http://dx.doi.org/10.21037/tau.2016.08.23
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author Abufaraj, Mohammad
Gust, Kilian
Moschini, Marco
Foerster, Beat
Soria, Francesco
Mathieu, Romain
Shariat, Shahrokh F.
author_facet Abufaraj, Mohammad
Gust, Kilian
Moschini, Marco
Foerster, Beat
Soria, Francesco
Mathieu, Romain
Shariat, Shahrokh F.
author_sort Abufaraj, Mohammad
collection PubMed
description Locally advanced (T3b, T4 and N1−N3) and metastatic urothelial bladder cancer (BCa) is a lethal disease with poor survival outcomes. Combination chemotherapy remains the treatment of choice in patients with metastatic disease and an important part of treatment in addition to radical cystectomy (RC) in patients with locally advanced tumour. Approximately half of patients who underwent RC for muscle invasive BCa relapse after surgery with either local recurrence or distant metastasis. This review focuses on the management of muscle invasive, locally advanced and metastatic BCa with emphasis on the role of surgery; to summarize the current knowledge in order to enhance clinical decision-making and counselling process.
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spelling pubmed-50711862016-10-26 Management of muscle invasive, locally advanced and metastatic urothelial carcinoma of the bladder: a literature review with emphasis on the role of surgery Abufaraj, Mohammad Gust, Kilian Moschini, Marco Foerster, Beat Soria, Francesco Mathieu, Romain Shariat, Shahrokh F. Transl Androl Urol Review Article Locally advanced (T3b, T4 and N1−N3) and metastatic urothelial bladder cancer (BCa) is a lethal disease with poor survival outcomes. Combination chemotherapy remains the treatment of choice in patients with metastatic disease and an important part of treatment in addition to radical cystectomy (RC) in patients with locally advanced tumour. Approximately half of patients who underwent RC for muscle invasive BCa relapse after surgery with either local recurrence or distant metastasis. This review focuses on the management of muscle invasive, locally advanced and metastatic BCa with emphasis on the role of surgery; to summarize the current knowledge in order to enhance clinical decision-making and counselling process. AME Publishing Company 2016-10 /pmc/articles/PMC5071186/ /pubmed/27785430 http://dx.doi.org/10.21037/tau.2016.08.23 Text en 2016 Translational Andrology and Urology. All rights reserved.
spellingShingle Review Article
Abufaraj, Mohammad
Gust, Kilian
Moschini, Marco
Foerster, Beat
Soria, Francesco
Mathieu, Romain
Shariat, Shahrokh F.
Management of muscle invasive, locally advanced and metastatic urothelial carcinoma of the bladder: a literature review with emphasis on the role of surgery
title Management of muscle invasive, locally advanced and metastatic urothelial carcinoma of the bladder: a literature review with emphasis on the role of surgery
title_full Management of muscle invasive, locally advanced and metastatic urothelial carcinoma of the bladder: a literature review with emphasis on the role of surgery
title_fullStr Management of muscle invasive, locally advanced and metastatic urothelial carcinoma of the bladder: a literature review with emphasis on the role of surgery
title_full_unstemmed Management of muscle invasive, locally advanced and metastatic urothelial carcinoma of the bladder: a literature review with emphasis on the role of surgery
title_short Management of muscle invasive, locally advanced and metastatic urothelial carcinoma of the bladder: a literature review with emphasis on the role of surgery
title_sort management of muscle invasive, locally advanced and metastatic urothelial carcinoma of the bladder: a literature review with emphasis on the role of surgery
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071186/
https://www.ncbi.nlm.nih.gov/pubmed/27785430
http://dx.doi.org/10.21037/tau.2016.08.23
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