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SPRYSEC Effectors: A Versatile Protein-Binding Platform to Disrupt Plant Innate Immunity
Persistent infections by sedentary plant-parasitic nematodes are a major threat to important food crops all over the world. These roundworms manipulate host plant cell morphology and physiology to establish sophisticated feeding structures. Key modifications to plant cells during their transition in...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071358/ https://www.ncbi.nlm.nih.gov/pubmed/27812363 http://dx.doi.org/10.3389/fpls.2016.01575 |
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author | Diaz-Granados, Amalia Petrescu, Andrei-José Goverse, Aska Smant, Geert |
author_facet | Diaz-Granados, Amalia Petrescu, Andrei-José Goverse, Aska Smant, Geert |
author_sort | Diaz-Granados, Amalia |
collection | PubMed |
description | Persistent infections by sedentary plant-parasitic nematodes are a major threat to important food crops all over the world. These roundworms manipulate host plant cell morphology and physiology to establish sophisticated feeding structures. Key modifications to plant cells during their transition into feeding structures are largely attributed to the activity of effectors secreted by the nematodes. The SPRYSEC effectors were initially identified in the potato cyst nematodes Globodera rostochiensis and G. pallida, and are characterized by a single SPRY domain, a non-catalytic domain present in modular proteins with different functions. The SPRY domain is wide-spread among eukaryotes and thought to be involved in mediating protein–protein interactions. Thus far, the SPRY domain is only reported as a functional domain in effectors of plant-parasitic nematodes, but not of other plant pathogens. SPRYSEC effectors have been implicated in both suppression and activation of plant immunity, but other possible roles in nematode virulence remain undefined. Here, we review the latest reports on the structure, function, and sequence diversity of SPRYSEC effectors, which provide support for a model featuring these effectors as a versatile protein-binding platform for the nematodes to target a wide range of host proteins during parasitism. |
format | Online Article Text |
id | pubmed-5071358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50713582016-11-03 SPRYSEC Effectors: A Versatile Protein-Binding Platform to Disrupt Plant Innate Immunity Diaz-Granados, Amalia Petrescu, Andrei-José Goverse, Aska Smant, Geert Front Plant Sci Plant Science Persistent infections by sedentary plant-parasitic nematodes are a major threat to important food crops all over the world. These roundworms manipulate host plant cell morphology and physiology to establish sophisticated feeding structures. Key modifications to plant cells during their transition into feeding structures are largely attributed to the activity of effectors secreted by the nematodes. The SPRYSEC effectors were initially identified in the potato cyst nematodes Globodera rostochiensis and G. pallida, and are characterized by a single SPRY domain, a non-catalytic domain present in modular proteins with different functions. The SPRY domain is wide-spread among eukaryotes and thought to be involved in mediating protein–protein interactions. Thus far, the SPRY domain is only reported as a functional domain in effectors of plant-parasitic nematodes, but not of other plant pathogens. SPRYSEC effectors have been implicated in both suppression and activation of plant immunity, but other possible roles in nematode virulence remain undefined. Here, we review the latest reports on the structure, function, and sequence diversity of SPRYSEC effectors, which provide support for a model featuring these effectors as a versatile protein-binding platform for the nematodes to target a wide range of host proteins during parasitism. Frontiers Media S.A. 2016-10-20 /pmc/articles/PMC5071358/ /pubmed/27812363 http://dx.doi.org/10.3389/fpls.2016.01575 Text en Copyright © 2016 Diaz-Granados, Petrescu, Goverse and Smant. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Plant Science Diaz-Granados, Amalia Petrescu, Andrei-José Goverse, Aska Smant, Geert SPRYSEC Effectors: A Versatile Protein-Binding Platform to Disrupt Plant Innate Immunity |
title | SPRYSEC Effectors: A Versatile Protein-Binding Platform to Disrupt Plant Innate Immunity |
title_full | SPRYSEC Effectors: A Versatile Protein-Binding Platform to Disrupt Plant Innate Immunity |
title_fullStr | SPRYSEC Effectors: A Versatile Protein-Binding Platform to Disrupt Plant Innate Immunity |
title_full_unstemmed | SPRYSEC Effectors: A Versatile Protein-Binding Platform to Disrupt Plant Innate Immunity |
title_short | SPRYSEC Effectors: A Versatile Protein-Binding Platform to Disrupt Plant Innate Immunity |
title_sort | sprysec effectors: a versatile protein-binding platform to disrupt plant innate immunity |
topic | Plant Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071358/ https://www.ncbi.nlm.nih.gov/pubmed/27812363 http://dx.doi.org/10.3389/fpls.2016.01575 |
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