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Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II

The reaction mechanism of DNA topoisomerase II (TOP2) involves a covalent double-strand break intermediate in which the enzyme is coupled to DNA via a 5′-phosphotyrosyl bond. This normally transient enzyme-bridged break is stabilised by drugs such as mitoxantrone, mAMSA, etoposide, doxorubicin, epir...

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Detalles Bibliográficos
Autores principales:	Lee, Ka C., Bramley, Rebecca L., Cowell, Ian G., Jackson, Graham H., Austin, Caroline A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071433/ https://www.ncbi.nlm.nih.gov/pubmed/26794000 http://dx.doi.org/10.1016/j.bcp.2015.12.015

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