Fbxw7 Deletion Accelerates Kras(G12D)-Driven Pancreatic Tumorigenesis via Yap Accumulation()()()

Pancreatic cancers driven by KRAS mutations require additional mutations for tumor progression. The tumor suppressor FBXW7 is altered in pancreatic cancers, but its contribution to pancreatic tumorigenesis is unknown. To determine potential cooperation between Kras mutation and Fbxw7 inactivation in...

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Detalles Bibliográficos
Autores principales: Zhang, Qiang, Zhang, Yaqing, Parsels, Joshua D., Lohse, Ines, Lawrence, Theodore S., Pasca di Magliano, Marina, Sun, Yi, Morgan, Meredith A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2016
Materias:
Short communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071541/
https://www.ncbi.nlm.nih.gov/pubmed/27764699
http://dx.doi.org/10.1016/j.neo.2016.08.009

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