Pharmacokinetics of H002, a novel S1PR(1) modulator, and its metabolites in rat blood using liquid chromatography–tandem mass spectrometry

A rapid and sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for the simultaneous determination of H002 and its phosphorylated metabolite, H002-P and hydroxylated metabolite H002-M, in rat blood. H001, an analogue of H002, was used as the interna...

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Detalles Bibliográficos
Autores principales: Mi, Jiaqi, Zhao, Manman, Yang, Shu, Yang, Shuang, Jin, Jing, Wang, Xiaojian, Xiao, Qiong, Hu, Jinping, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071622/
https://www.ncbi.nlm.nih.gov/pubmed/27818925
http://dx.doi.org/10.1016/j.apsb.2016.06.001

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