New techniques of on-line biological sample processing and their application in the field of biopharmaceutical analysis

Biological sample pretreatment is an important step in biological sample analysis. Due to the diversity of biological matrices, the analysis of target substances in these samples presents significant challenges to sample processing. To meet these emerging demands on biopharmaceutical analysis, this...

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Detalles Bibliográficos
Autores principales: Peng, Jie, Tang, Fang, Zhou, Rui, Xie, Xiang, Li, Sanwang, Xie, Feifan, Yu, Peng, Mu, Lingli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071623/
https://www.ncbi.nlm.nih.gov/pubmed/27818920
http://dx.doi.org/10.1016/j.apsb.2016.05.016
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author Peng, Jie
Tang, Fang
Zhou, Rui
Xie, Xiang
Li, Sanwang
Xie, Feifan
Yu, Peng
Mu, Lingli
author_facet Peng, Jie
Tang, Fang
Zhou, Rui
Xie, Xiang
Li, Sanwang
Xie, Feifan
Yu, Peng
Mu, Lingli
author_sort Peng, Jie
collection PubMed
description Biological sample pretreatment is an important step in biological sample analysis. Due to the diversity of biological matrices, the analysis of target substances in these samples presents significant challenges to sample processing. To meet these emerging demands on biopharmaceutical analysis, this paper summarizes several new techniques of on-line biological sample processing: solid phase extraction, solid phase micro-extraction, column switching, limited intake filler, molecularly imprinted solid phase extraction, tubular column, and micro-dialysis. We describe new developments, principles, and characteristics of these techniques, and the application of liquid chromatography–mass spectrometry (LC–MS) in biopharmaceutical analysis with these new techniques in on-line biological sample processing.
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spelling pubmed-50716232016-11-04 New techniques of on-line biological sample processing and their application in the field of biopharmaceutical analysis Peng, Jie Tang, Fang Zhou, Rui Xie, Xiang Li, Sanwang Xie, Feifan Yu, Peng Mu, Lingli Acta Pharm Sin B Review Biological sample pretreatment is an important step in biological sample analysis. Due to the diversity of biological matrices, the analysis of target substances in these samples presents significant challenges to sample processing. To meet these emerging demands on biopharmaceutical analysis, this paper summarizes several new techniques of on-line biological sample processing: solid phase extraction, solid phase micro-extraction, column switching, limited intake filler, molecularly imprinted solid phase extraction, tubular column, and micro-dialysis. We describe new developments, principles, and characteristics of these techniques, and the application of liquid chromatography–mass spectrometry (LC–MS) in biopharmaceutical analysis with these new techniques in on-line biological sample processing. Elsevier 2016-11 2016-06-23 /pmc/articles/PMC5071623/ /pubmed/27818920 http://dx.doi.org/10.1016/j.apsb.2016.05.016 Text en © 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Peng, Jie
Tang, Fang
Zhou, Rui
Xie, Xiang
Li, Sanwang
Xie, Feifan
Yu, Peng
Mu, Lingli
New techniques of on-line biological sample processing and their application in the field of biopharmaceutical analysis
title New techniques of on-line biological sample processing and their application in the field of biopharmaceutical analysis
title_full New techniques of on-line biological sample processing and their application in the field of biopharmaceutical analysis
title_fullStr New techniques of on-line biological sample processing and their application in the field of biopharmaceutical analysis
title_full_unstemmed New techniques of on-line biological sample processing and their application in the field of biopharmaceutical analysis
title_short New techniques of on-line biological sample processing and their application in the field of biopharmaceutical analysis
title_sort new techniques of on-line biological sample processing and their application in the field of biopharmaceutical analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071623/
https://www.ncbi.nlm.nih.gov/pubmed/27818920
http://dx.doi.org/10.1016/j.apsb.2016.05.016
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