MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics

MicroRNAs (miRNAs) are a class of phylogenetically conserved, non-coding short RNAs, 19–22 nt in length which suppress protein expression through base-pairing with the 3′-untranslated region of target mRNAs. miRNAs have been found to participate in cell proliferation, differentiation and apoptosis....

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Detalles Bibliográficos
Autores principales: Li, Huimin, Zhao, Xiaoguang, Shan, Hongli, Liang, Haihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071633/
https://www.ncbi.nlm.nih.gov/pubmed/27818919
http://dx.doi.org/10.1016/j.apsb.2016.06.010
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author Li, Huimin
Zhao, Xiaoguang
Shan, Hongli
Liang, Haihai
author_facet Li, Huimin
Zhao, Xiaoguang
Shan, Hongli
Liang, Haihai
author_sort Li, Huimin
collection PubMed
description MicroRNAs (miRNAs) are a class of phylogenetically conserved, non-coding short RNAs, 19–22 nt in length which suppress protein expression through base-pairing with the 3′-untranslated region of target mRNAs. miRNAs have been found to participate in cell proliferation, differentiation and apoptosis. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and high lethality fibrotic lung disease for which currently there is no effective treatment. Some miRNAs have been reported to be involved in the pathogenesis of pulmonary fibrosis. In this review, we discuss the role of miRNAs in the pathogenesis, diagnosis and treatment of IPF.
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spelling pubmed-50716332016-11-04 MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics Li, Huimin Zhao, Xiaoguang Shan, Hongli Liang, Haihai Acta Pharm Sin B Review MicroRNAs (miRNAs) are a class of phylogenetically conserved, non-coding short RNAs, 19–22 nt in length which suppress protein expression through base-pairing with the 3′-untranslated region of target mRNAs. miRNAs have been found to participate in cell proliferation, differentiation and apoptosis. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and high lethality fibrotic lung disease for which currently there is no effective treatment. Some miRNAs have been reported to be involved in the pathogenesis of pulmonary fibrosis. In this review, we discuss the role of miRNAs in the pathogenesis, diagnosis and treatment of IPF. Elsevier 2016-11 2016-07-27 /pmc/articles/PMC5071633/ /pubmed/27818919 http://dx.doi.org/10.1016/j.apsb.2016.06.010 Text en © 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Li, Huimin
Zhao, Xiaoguang
Shan, Hongli
Liang, Haihai
MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics
title MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics
title_full MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics
title_fullStr MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics
title_full_unstemmed MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics
title_short MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics
title_sort micrornas in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071633/
https://www.ncbi.nlm.nih.gov/pubmed/27818919
http://dx.doi.org/10.1016/j.apsb.2016.06.010
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