Cargando…

Effects of a New Emollient‐Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis

BACKGROUND/OBJECTIVES: The use of emollients is widely recommended for the management of atopic dermatitis (AD), especially between flares. An imbalance of skin microflora is suspected of playing a key role in exacerbations of AD. Our aim was to evaluate the effect of a new emollient balm on clinica...

Descripción completa

Detalles Bibliográficos
Autores principales: Bianchi, Pascale, Theunis, Jennifer, Casas, Christiane, Villeneuve, Cecile, Patrizi, Annalisa, Phulpin, Chloe, Bacquey, Adeline, Redoulès, Daniel, Mengeaud, Valerie, Schmitt, Anne‐Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071726/
https://www.ncbi.nlm.nih.gov/pubmed/27001317
http://dx.doi.org/10.1111/pde.12786
_version_ 1782461316574740480
author Bianchi, Pascale
Theunis, Jennifer
Casas, Christiane
Villeneuve, Cecile
Patrizi, Annalisa
Phulpin, Chloe
Bacquey, Adeline
Redoulès, Daniel
Mengeaud, Valerie
Schmitt, Anne‐Marie
author_facet Bianchi, Pascale
Theunis, Jennifer
Casas, Christiane
Villeneuve, Cecile
Patrizi, Annalisa
Phulpin, Chloe
Bacquey, Adeline
Redoulès, Daniel
Mengeaud, Valerie
Schmitt, Anne‐Marie
author_sort Bianchi, Pascale
collection PubMed
description BACKGROUND/OBJECTIVES: The use of emollients is widely recommended for the management of atopic dermatitis (AD), especially between flares. An imbalance of skin microflora is suspected of playing a key role in exacerbations of AD. Our aim was to evaluate the effect of a new emollient balm on clinical parameters (SCORing Atopic Dermatitis [SCORAD], xerosis, pruritus), skin barrier function (transepidermal water loss and loricrin, filaggrin, corneodesmosin, and involucrin expression], skin microflora biodiversity, and Staphylococcus aureus and Staphylococcus epidermidis balance in children with mild AD. METHODS: Fifty‐four children (1–4 yrs old) were enrolled in this randomized, controlled study. Subjects applied a hygiene product and the emollient balm (emollient group, n = 28) or the hygiene product only (control group, n = 26) twice a day for 28 days. RESULTS: We found improvement in favor of the emollient group in SCORAD (p < 0.001), pruritus (p = 0.06), and xerosis (p = 0.06) after 28 days of application. Moreover, transepidermal water loss decreased in the emollient group by 34% (p = 0.06) and involucrin expression by 37% (p = 0.001) at day 28 from baseline in association with improvement in barrier function, whereas other barrier‐specific proteins did not vary. S. aureus increased significantly in the control group only (6.5 times, p = 0.01), whereas S. epidermidis remained stable in both groups. The Shannon index (H′ = 2.3) did not vary with treatment in either group. CONCLUSION: Twice‐daily application of a new emollient balm in children with mild AD protected the skin from S. aureus proliferation and preserved microflora biodiversity.
format Online
Article
Text
id pubmed-5071726
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-50717262016-11-02 Effects of a New Emollient‐Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis Bianchi, Pascale Theunis, Jennifer Casas, Christiane Villeneuve, Cecile Patrizi, Annalisa Phulpin, Chloe Bacquey, Adeline Redoulès, Daniel Mengeaud, Valerie Schmitt, Anne‐Marie Pediatr Dermatol Original Articles BACKGROUND/OBJECTIVES: The use of emollients is widely recommended for the management of atopic dermatitis (AD), especially between flares. An imbalance of skin microflora is suspected of playing a key role in exacerbations of AD. Our aim was to evaluate the effect of a new emollient balm on clinical parameters (SCORing Atopic Dermatitis [SCORAD], xerosis, pruritus), skin barrier function (transepidermal water loss and loricrin, filaggrin, corneodesmosin, and involucrin expression], skin microflora biodiversity, and Staphylococcus aureus and Staphylococcus epidermidis balance in children with mild AD. METHODS: Fifty‐four children (1–4 yrs old) were enrolled in this randomized, controlled study. Subjects applied a hygiene product and the emollient balm (emollient group, n = 28) or the hygiene product only (control group, n = 26) twice a day for 28 days. RESULTS: We found improvement in favor of the emollient group in SCORAD (p < 0.001), pruritus (p = 0.06), and xerosis (p = 0.06) after 28 days of application. Moreover, transepidermal water loss decreased in the emollient group by 34% (p = 0.06) and involucrin expression by 37% (p = 0.001) at day 28 from baseline in association with improvement in barrier function, whereas other barrier‐specific proteins did not vary. S. aureus increased significantly in the control group only (6.5 times, p = 0.01), whereas S. epidermidis remained stable in both groups. The Shannon index (H′ = 2.3) did not vary with treatment in either group. CONCLUSION: Twice‐daily application of a new emollient balm in children with mild AD protected the skin from S. aureus proliferation and preserved microflora biodiversity. John Wiley and Sons Inc. 2016-03-21 2016 /pmc/articles/PMC5071726/ /pubmed/27001317 http://dx.doi.org/10.1111/pde.12786 Text en © 2016 Pierre Fabre Dermo‐Cosmétique. Pediatric Dermatology published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Bianchi, Pascale
Theunis, Jennifer
Casas, Christiane
Villeneuve, Cecile
Patrizi, Annalisa
Phulpin, Chloe
Bacquey, Adeline
Redoulès, Daniel
Mengeaud, Valerie
Schmitt, Anne‐Marie
Effects of a New Emollient‐Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis
title Effects of a New Emollient‐Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis
title_full Effects of a New Emollient‐Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis
title_fullStr Effects of a New Emollient‐Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis
title_full_unstemmed Effects of a New Emollient‐Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis
title_short Effects of a New Emollient‐Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis
title_sort effects of a new emollient‐based treatment on skin microflora balance and barrier function in children with mild atopic dermatitis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071726/
https://www.ncbi.nlm.nih.gov/pubmed/27001317
http://dx.doi.org/10.1111/pde.12786
work_keys_str_mv AT bianchipascale effectsofanewemollientbasedtreatmentonskinmicroflorabalanceandbarrierfunctioninchildrenwithmildatopicdermatitis
AT theunisjennifer effectsofanewemollientbasedtreatmentonskinmicroflorabalanceandbarrierfunctioninchildrenwithmildatopicdermatitis
AT casaschristiane effectsofanewemollientbasedtreatmentonskinmicroflorabalanceandbarrierfunctioninchildrenwithmildatopicdermatitis
AT villeneuvececile effectsofanewemollientbasedtreatmentonskinmicroflorabalanceandbarrierfunctioninchildrenwithmildatopicdermatitis
AT patriziannalisa effectsofanewemollientbasedtreatmentonskinmicroflorabalanceandbarrierfunctioninchildrenwithmildatopicdermatitis
AT phulpinchloe effectsofanewemollientbasedtreatmentonskinmicroflorabalanceandbarrierfunctioninchildrenwithmildatopicdermatitis
AT bacqueyadeline effectsofanewemollientbasedtreatmentonskinmicroflorabalanceandbarrierfunctioninchildrenwithmildatopicdermatitis
AT redoulesdaniel effectsofanewemollientbasedtreatmentonskinmicroflorabalanceandbarrierfunctioninchildrenwithmildatopicdermatitis
AT mengeaudvalerie effectsofanewemollientbasedtreatmentonskinmicroflorabalanceandbarrierfunctioninchildrenwithmildatopicdermatitis
AT schmittannemarie effectsofanewemollientbasedtreatmentonskinmicroflorabalanceandbarrierfunctioninchildrenwithmildatopicdermatitis