Cargando…

Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study

This study was carried out to explore associations between assisted reproductive technology (ART) and maternal and neonatal outcomes compared with similar outcomes following spontaneously conceived births. We conducted a retrospective cohort study of pregnancies conceived by ART (N = 2641) during 20...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Linling, Zhang, Yu, Liu, Yifeng, Zhang, Runjv, Wu, Yiqing, Huang, Yun, Liu, Feng, Li, Meigen, Sun, Saijun, Xing, Lanfeng, Zhu, Yimin, Chen, Yiyi, Xu, Li, Zhou, Liangbi, Huang, Hefeng, Zhang, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071829/
https://www.ncbi.nlm.nih.gov/pubmed/27762324
http://dx.doi.org/10.1038/srep35141
_version_ 1782461332402995200
author Zhu, Linling
Zhang, Yu
Liu, Yifeng
Zhang, Runjv
Wu, Yiqing
Huang, Yun
Liu, Feng
Li, Meigen
Sun, Saijun
Xing, Lanfeng
Zhu, Yimin
Chen, Yiyi
Xu, Li
Zhou, Liangbi
Huang, Hefeng
Zhang, Dan
author_facet Zhu, Linling
Zhang, Yu
Liu, Yifeng
Zhang, Runjv
Wu, Yiqing
Huang, Yun
Liu, Feng
Li, Meigen
Sun, Saijun
Xing, Lanfeng
Zhu, Yimin
Chen, Yiyi
Xu, Li
Zhou, Liangbi
Huang, Hefeng
Zhang, Dan
author_sort Zhu, Linling
collection PubMed
description This study was carried out to explore associations between assisted reproductive technology (ART) and maternal and neonatal outcomes compared with similar outcomes following spontaneously conceived births. We conducted a retrospective cohort study of pregnancies conceived by ART (N = 2641) during 2006–2014 compared to naturally conceived pregnancies (N = 5282) after matching for maternal age and birth year. Pregnancy complications, perinatal complications and neonatal outcomes of enrolled subjects were investigated and analysed by multivariate logistic regression. We found that pregnancies conceived by in vitro fertilization (IVF) were associated with a significantly increased incidence of gestational diabetes mellitus, gestational hypertension, preeclampsia, intrahepatic cholestasis of pregnancy, placenta previa, placental abruption, preterm premature rupture of membranes, placental adherence, postpartum haemorrhage, polyhydramnios, preterm labour, low birth weight, and small-for-date infant compared with spontaneously conceived births. Pregnancies conceived by intracytoplasmic sperm injection (ICSI) showed similar elevated complications, except some of the difference narrowed or disappeared. Singleton pregnancies or nulliparous pregnancies following ART still exhibited increased maternal and neonatal complications. Therefore, we conclude that pregnancies conceived following ART are at increased risks of antenatal complications, perinatal complications and poor neonatal outcomes, which may result from not only a higher incidence of multiple pregnancy, but also the manipulation involved in ART processes.
format Online
Article
Text
id pubmed-5071829
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-50718292016-10-26 Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study Zhu, Linling Zhang, Yu Liu, Yifeng Zhang, Runjv Wu, Yiqing Huang, Yun Liu, Feng Li, Meigen Sun, Saijun Xing, Lanfeng Zhu, Yimin Chen, Yiyi Xu, Li Zhou, Liangbi Huang, Hefeng Zhang, Dan Sci Rep Article This study was carried out to explore associations between assisted reproductive technology (ART) and maternal and neonatal outcomes compared with similar outcomes following spontaneously conceived births. We conducted a retrospective cohort study of pregnancies conceived by ART (N = 2641) during 2006–2014 compared to naturally conceived pregnancies (N = 5282) after matching for maternal age and birth year. Pregnancy complications, perinatal complications and neonatal outcomes of enrolled subjects were investigated and analysed by multivariate logistic regression. We found that pregnancies conceived by in vitro fertilization (IVF) were associated with a significantly increased incidence of gestational diabetes mellitus, gestational hypertension, preeclampsia, intrahepatic cholestasis of pregnancy, placenta previa, placental abruption, preterm premature rupture of membranes, placental adherence, postpartum haemorrhage, polyhydramnios, preterm labour, low birth weight, and small-for-date infant compared with spontaneously conceived births. Pregnancies conceived by intracytoplasmic sperm injection (ICSI) showed similar elevated complications, except some of the difference narrowed or disappeared. Singleton pregnancies or nulliparous pregnancies following ART still exhibited increased maternal and neonatal complications. Therefore, we conclude that pregnancies conceived following ART are at increased risks of antenatal complications, perinatal complications and poor neonatal outcomes, which may result from not only a higher incidence of multiple pregnancy, but also the manipulation involved in ART processes. Nature Publishing Group 2016-10-20 /pmc/articles/PMC5071829/ /pubmed/27762324 http://dx.doi.org/10.1038/srep35141 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhu, Linling
Zhang, Yu
Liu, Yifeng
Zhang, Runjv
Wu, Yiqing
Huang, Yun
Liu, Feng
Li, Meigen
Sun, Saijun
Xing, Lanfeng
Zhu, Yimin
Chen, Yiyi
Xu, Li
Zhou, Liangbi
Huang, Hefeng
Zhang, Dan
Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study
title Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study
title_full Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study
title_fullStr Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study
title_full_unstemmed Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study
title_short Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study
title_sort maternal and live-birth outcomes of pregnancies following assisted reproductive technology: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071829/
https://www.ncbi.nlm.nih.gov/pubmed/27762324
http://dx.doi.org/10.1038/srep35141
work_keys_str_mv AT zhulinling maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy
AT zhangyu maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy
AT liuyifeng maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy
AT zhangrunjv maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy
AT wuyiqing maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy
AT huangyun maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy
AT liufeng maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy
AT limeigen maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy
AT sunsaijun maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy
AT xinglanfeng maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy
AT zhuyimin maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy
AT chenyiyi maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy
AT xuli maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy
AT zhouliangbi maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy
AT huanghefeng maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy
AT zhangdan maternalandlivebirthoutcomesofpregnanciesfollowingassistedreproductivetechnologyaretrospectivecohortstudy