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Dynamic Drug-Induced Sleep Computed Tomography in Adults With Obstructive Sleep Apnea
Surgical success for obstructive sleep apnea (OSA) depends on identifying sites of obstruction in the upper airway. In this study, we investigated sites of obstruction by evaluating dynamic changes in the upper airway using drug-induced sleep computed tomography (DI-SCT) in patients with OSA. Thirty...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071907/ https://www.ncbi.nlm.nih.gov/pubmed/27762308 http://dx.doi.org/10.1038/srep35849 |
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author | Li, Hsueh-Yu Lo, Yu-Lun Wang, Chao-Jan Hsin, Li-Jen Lin, Wan-Ni Fang, Tuan-Jen Lee, Li-Ang |
author_facet | Li, Hsueh-Yu Lo, Yu-Lun Wang, Chao-Jan Hsin, Li-Jen Lin, Wan-Ni Fang, Tuan-Jen Lee, Li-Ang |
author_sort | Li, Hsueh-Yu |
collection | PubMed |
description | Surgical success for obstructive sleep apnea (OSA) depends on identifying sites of obstruction in the upper airway. In this study, we investigated sites of obstruction by evaluating dynamic changes in the upper airway using drug-induced sleep computed tomography (DI-SCT) in patients with OSA. Thirty-five adult patients with OSA were prospectively enrolled. Sleep was induced with propofol under light sedation (bispectral index 70–75), and low-dose 320-detector row CT was performed for 10 seconds over a span of 2–3 respiratory cycles with supporting a continuous positive airway pressure model. Most (89%) of the patients had multi-level obstructions. Total obstruction most commonly occurred in the velum (86%), followed by the tongue (57%), oropharyngeal lateral wall (49%), and epiglottis (26%). There were two types of anterior-posterior obstruction of the soft palate, uvular (94%) and velar (6%), and three types of tongue obstruction, upper (30%), lower (37%), and upper plus lower obstruction (33%). DI-SCT is a fast and safe tool to identify simulated sleep airway obstruction in patients with OSA. It provides data on dynamic airway movement in the sagittal view which can be used to differentiate palate and tongue obstructions, and this can be helpful when planning surgery for patients with OSA. |
format | Online Article Text |
id | pubmed-5071907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50719072016-10-26 Dynamic Drug-Induced Sleep Computed Tomography in Adults With Obstructive Sleep Apnea Li, Hsueh-Yu Lo, Yu-Lun Wang, Chao-Jan Hsin, Li-Jen Lin, Wan-Ni Fang, Tuan-Jen Lee, Li-Ang Sci Rep Article Surgical success for obstructive sleep apnea (OSA) depends on identifying sites of obstruction in the upper airway. In this study, we investigated sites of obstruction by evaluating dynamic changes in the upper airway using drug-induced sleep computed tomography (DI-SCT) in patients with OSA. Thirty-five adult patients with OSA were prospectively enrolled. Sleep was induced with propofol under light sedation (bispectral index 70–75), and low-dose 320-detector row CT was performed for 10 seconds over a span of 2–3 respiratory cycles with supporting a continuous positive airway pressure model. Most (89%) of the patients had multi-level obstructions. Total obstruction most commonly occurred in the velum (86%), followed by the tongue (57%), oropharyngeal lateral wall (49%), and epiglottis (26%). There were two types of anterior-posterior obstruction of the soft palate, uvular (94%) and velar (6%), and three types of tongue obstruction, upper (30%), lower (37%), and upper plus lower obstruction (33%). DI-SCT is a fast and safe tool to identify simulated sleep airway obstruction in patients with OSA. It provides data on dynamic airway movement in the sagittal view which can be used to differentiate palate and tongue obstructions, and this can be helpful when planning surgery for patients with OSA. Nature Publishing Group 2016-10-20 /pmc/articles/PMC5071907/ /pubmed/27762308 http://dx.doi.org/10.1038/srep35849 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Li, Hsueh-Yu Lo, Yu-Lun Wang, Chao-Jan Hsin, Li-Jen Lin, Wan-Ni Fang, Tuan-Jen Lee, Li-Ang Dynamic Drug-Induced Sleep Computed Tomography in Adults With Obstructive Sleep Apnea |
title | Dynamic Drug-Induced Sleep Computed Tomography in Adults With Obstructive Sleep Apnea |
title_full | Dynamic Drug-Induced Sleep Computed Tomography in Adults With Obstructive Sleep Apnea |
title_fullStr | Dynamic Drug-Induced Sleep Computed Tomography in Adults With Obstructive Sleep Apnea |
title_full_unstemmed | Dynamic Drug-Induced Sleep Computed Tomography in Adults With Obstructive Sleep Apnea |
title_short | Dynamic Drug-Induced Sleep Computed Tomography in Adults With Obstructive Sleep Apnea |
title_sort | dynamic drug-induced sleep computed tomography in adults with obstructive sleep apnea |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071907/ https://www.ncbi.nlm.nih.gov/pubmed/27762308 http://dx.doi.org/10.1038/srep35849 |
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