On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury

The role of peroxisome proliferator-activated receptor α (PPARα)-mediated metabolic remodeling in cardiac adaptation to hypoxia has yet to be defined. Here, mice were housed in hypoxia for 3 wk before in vivo contractile function was measured using cine MRI. In isolated, perfused hearts, energetics...

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Detalles Bibliográficos
Autores principales: Cole, Mark A., Abd Jamil, Amira H., Heather, Lisa C., Murray, Andrew J., Sutton, Elizabeth R., Slingo, Mary, Sebag-Montefiore, Liam, Tan, Suat Cheng, Aksentijević, Dunja, Gildea, Ottilie S., Stuckey, Daniel J., Yeoh, Kar Kheng, Carr, Carolyn A., Evans, Rhys D., Aasum, Ellen, Schofield, Christopher J., Ratcliffe, Peter J., Neubauer, Stefan, Robbins, Peter A., Clarke, Kieran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072355/
https://www.ncbi.nlm.nih.gov/pubmed/27103577
http://dx.doi.org/10.1096/fj.201500094R

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