MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer

BACKGROUND: Breast cancer is the main type of cancer in women, and triple-negative breast cancer (TNBC) is a unique subtype of breast cancer. The expression of miR-940 has been shown to play an important role in various cancers; however, the role of miR-940 in TNBC remains unknown. MATERIAL/METHODS:...

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Detalles Bibliográficos
Autores principales: Hou, Lingmi, Chen, Maoshan, Yang, Hongwei, Xing, Tianyong, Li, Jingdong, Li, Guangwu, Zhang, Lina, Deng, Shishan, Hu, Jiani, Zhao, Xiaobo, Jiang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2016
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072378/
https://www.ncbi.nlm.nih.gov/pubmed/27731867
http://dx.doi.org/10.12659/MSM.897731
Descripción
Sumario:BACKGROUND: Breast cancer is the main type of cancer in women, and triple-negative breast cancer (TNBC) is a unique subtype of breast cancer. The expression of miR-940 has been shown to play an important role in various cancers; however, the role of miR-940 in TNBC remains unknown. MATERIAL/METHODS: The expression of miR-940 in TNBC tissues or cells were tested by qRT-PCR; the expression of miR-940 in cells were overexpressed by miR-940 mimics, and suppressed by anti-miR-940. Bioinformatics algorithms from TargetScanHuman were used to predict the target genes of miR-940. The interaction between miR-940 and ZNF24 was confirmed by dual luciferase assays. The protein level was assayed by Western blot. RESULTS: TNBC tissues and cells showed lower miR-940 levels. CONCLUSIONS: MiR-940 inhibited cellular proliferation and migration in TNBC.

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