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MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer
BACKGROUND: Breast cancer is the main type of cancer in women, and triple-negative breast cancer (TNBC) is a unique subtype of breast cancer. The expression of miR-940 has been shown to play an important role in various cancers; however, the role of miR-940 in TNBC remains unknown. MATERIAL/METHODS:...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072378/ https://www.ncbi.nlm.nih.gov/pubmed/27731867 http://dx.doi.org/10.12659/MSM.897731 |
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author | Hou, Lingmi Chen, Maoshan Yang, Hongwei Xing, Tianyong Li, Jingdong Li, Guangwu Zhang, Lina Deng, Shishan Hu, Jiani Zhao, Xiaobo Jiang, Jun |
author_facet | Hou, Lingmi Chen, Maoshan Yang, Hongwei Xing, Tianyong Li, Jingdong Li, Guangwu Zhang, Lina Deng, Shishan Hu, Jiani Zhao, Xiaobo Jiang, Jun |
author_sort | Hou, Lingmi |
collection | PubMed |
description | BACKGROUND: Breast cancer is the main type of cancer in women, and triple-negative breast cancer (TNBC) is a unique subtype of breast cancer. The expression of miR-940 has been shown to play an important role in various cancers; however, the role of miR-940 in TNBC remains unknown. MATERIAL/METHODS: The expression of miR-940 in TNBC tissues or cells were tested by qRT-PCR; the expression of miR-940 in cells were overexpressed by miR-940 mimics, and suppressed by anti-miR-940. Bioinformatics algorithms from TargetScanHuman were used to predict the target genes of miR-940. The interaction between miR-940 and ZNF24 was confirmed by dual luciferase assays. The protein level was assayed by Western blot. RESULTS: TNBC tissues and cells showed lower miR-940 levels. CONCLUSIONS: MiR-940 inhibited cellular proliferation and migration in TNBC. |
format | Online Article Text |
id | pubmed-5072378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50723782016-10-27 MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer Hou, Lingmi Chen, Maoshan Yang, Hongwei Xing, Tianyong Li, Jingdong Li, Guangwu Zhang, Lina Deng, Shishan Hu, Jiani Zhao, Xiaobo Jiang, Jun Med Sci Monit Molecular Biology BACKGROUND: Breast cancer is the main type of cancer in women, and triple-negative breast cancer (TNBC) is a unique subtype of breast cancer. The expression of miR-940 has been shown to play an important role in various cancers; however, the role of miR-940 in TNBC remains unknown. MATERIAL/METHODS: The expression of miR-940 in TNBC tissues or cells were tested by qRT-PCR; the expression of miR-940 in cells were overexpressed by miR-940 mimics, and suppressed by anti-miR-940. Bioinformatics algorithms from TargetScanHuman were used to predict the target genes of miR-940. The interaction between miR-940 and ZNF24 was confirmed by dual luciferase assays. The protein level was assayed by Western blot. RESULTS: TNBC tissues and cells showed lower miR-940 levels. CONCLUSIONS: MiR-940 inhibited cellular proliferation and migration in TNBC. International Scientific Literature, Inc. 2016-10-12 /pmc/articles/PMC5072378/ /pubmed/27731867 http://dx.doi.org/10.12659/MSM.897731 Text en © Med Sci Monit, 2016 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) |
spellingShingle | Molecular Biology Hou, Lingmi Chen, Maoshan Yang, Hongwei Xing, Tianyong Li, Jingdong Li, Guangwu Zhang, Lina Deng, Shishan Hu, Jiani Zhao, Xiaobo Jiang, Jun MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer |
title | MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer |
title_full | MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer |
title_fullStr | MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer |
title_full_unstemmed | MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer |
title_short | MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer |
title_sort | mir-940 inhibited cell growth and migration in triple-negative breast cancer |
topic | Molecular Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072378/ https://www.ncbi.nlm.nih.gov/pubmed/27731867 http://dx.doi.org/10.12659/MSM.897731 |
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