RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

Necroptosis is a caspase-independent form of cell death that is triggered by activation of the receptor interacting serine/threonine kinase 3 (RIPK3) and phosphorylation of its pseudokinase substrate mixed lineage kinase-like (MLKL), which then translocates to membranes and promotes cell lysis. Acti...

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Detalles Bibliográficos
Autores principales: Newton, K, Dugger, D L, Maltzman, A, Greve, J M, Hedehus, M, Martin-McNulty, B, Carano, R A D, Cao, T C, van Bruggen, N, Bernstein, L, Lee, W P, Wu, X, DeVoss, J, Zhang, J, Jeet, S, Peng, I, McKenzie, B S, Roose-Girma, M, Caplazi, P, Diehl, L, Webster, J D, Vucic, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072432/
https://www.ncbi.nlm.nih.gov/pubmed/27177019
http://dx.doi.org/10.1038/cdd.2016.46

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