Cargando…
Maternal Vitamin D Status at Week 30 of Gestation and Offspring Cardio-Metabolic Health at 20 Years: A Prospective Cohort Study over Two Decades
BACKGROUND/OBJECTIVES: Vitamin D deficiency is common among pregnant women and since the fetus relies exclusively on maternal supply, deficiency could potentially interfere with fetal development. Vitamin D blood concentrations during pregnancy have been associated with offspring cardio-metabolic he...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072548/ https://www.ncbi.nlm.nih.gov/pubmed/27764169 http://dx.doi.org/10.1371/journal.pone.0164758 |
_version_ | 1782461409502691328 |
---|---|
author | Rytter, Dorte Bech, Bodil Hammer Halldorsson, Thorhallur Ingi Henriksen, Tine Brink Grandström, Charlotta Cohen, Arieh Olsen, Sjurdur Frodi |
author_facet | Rytter, Dorte Bech, Bodil Hammer Halldorsson, Thorhallur Ingi Henriksen, Tine Brink Grandström, Charlotta Cohen, Arieh Olsen, Sjurdur Frodi |
author_sort | Rytter, Dorte |
collection | PubMed |
description | BACKGROUND/OBJECTIVES: Vitamin D deficiency is common among pregnant women and since the fetus relies exclusively on maternal supply, deficiency could potentially interfere with fetal development. Vitamin D blood concentrations during pregnancy have been associated with offspring cardio-metabolic health in a few previous studies but the evidence is still inconsistent and only one previous study has followed the offspring into adulthood. The aim of the present study was to investigate the association between maternal serum concentration of vitamin D (25(OH)D) in week 30 of gestation and offspring cardio-metabolic risk factors at 20 years. SUBJECTS/METHODS: A follow up study of a Danish birth cohort from 1988–89 (n = 965) was conducted. A blood sample was drawn from the women in week 30 of gestation. In 2008–2009, 95% of the original mother and child dyads could be identified in the central registration registry and were alive and living in Denmark. The offspring were followed up with self-reported anthropometrics (N = 629, 69%) and a clinical examination (N = 410, 45%). Multiple linear regression was used to estimate the association between maternal 25(OH)D and offspring cardio-metabolic risk factors adjusting for potential confounders. RESULTS: No overall association was observed between maternal 25(OH)D in week 30 of gestation and offspring cardio-metabolic risk factors. However, the analyses did suggest a possible inverse association with blood pressure in females. CONCLUSIONS: No clear association between maternal 25(OH)D concentration in week 30 of gestation and cardio-metabolic risk factors in the 20 year old offspring was found. |
format | Online Article Text |
id | pubmed-5072548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-50725482016-10-27 Maternal Vitamin D Status at Week 30 of Gestation and Offspring Cardio-Metabolic Health at 20 Years: A Prospective Cohort Study over Two Decades Rytter, Dorte Bech, Bodil Hammer Halldorsson, Thorhallur Ingi Henriksen, Tine Brink Grandström, Charlotta Cohen, Arieh Olsen, Sjurdur Frodi PLoS One Research Article BACKGROUND/OBJECTIVES: Vitamin D deficiency is common among pregnant women and since the fetus relies exclusively on maternal supply, deficiency could potentially interfere with fetal development. Vitamin D blood concentrations during pregnancy have been associated with offspring cardio-metabolic health in a few previous studies but the evidence is still inconsistent and only one previous study has followed the offspring into adulthood. The aim of the present study was to investigate the association between maternal serum concentration of vitamin D (25(OH)D) in week 30 of gestation and offspring cardio-metabolic risk factors at 20 years. SUBJECTS/METHODS: A follow up study of a Danish birth cohort from 1988–89 (n = 965) was conducted. A blood sample was drawn from the women in week 30 of gestation. In 2008–2009, 95% of the original mother and child dyads could be identified in the central registration registry and were alive and living in Denmark. The offspring were followed up with self-reported anthropometrics (N = 629, 69%) and a clinical examination (N = 410, 45%). Multiple linear regression was used to estimate the association between maternal 25(OH)D and offspring cardio-metabolic risk factors adjusting for potential confounders. RESULTS: No overall association was observed between maternal 25(OH)D in week 30 of gestation and offspring cardio-metabolic risk factors. However, the analyses did suggest a possible inverse association with blood pressure in females. CONCLUSIONS: No clear association between maternal 25(OH)D concentration in week 30 of gestation and cardio-metabolic risk factors in the 20 year old offspring was found. Public Library of Science 2016-10-20 /pmc/articles/PMC5072548/ /pubmed/27764169 http://dx.doi.org/10.1371/journal.pone.0164758 Text en © 2016 Rytter et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Rytter, Dorte Bech, Bodil Hammer Halldorsson, Thorhallur Ingi Henriksen, Tine Brink Grandström, Charlotta Cohen, Arieh Olsen, Sjurdur Frodi Maternal Vitamin D Status at Week 30 of Gestation and Offspring Cardio-Metabolic Health at 20 Years: A Prospective Cohort Study over Two Decades |
title | Maternal Vitamin D Status at Week 30 of Gestation and Offspring Cardio-Metabolic Health at 20 Years: A Prospective Cohort Study over Two Decades |
title_full | Maternal Vitamin D Status at Week 30 of Gestation and Offspring Cardio-Metabolic Health at 20 Years: A Prospective Cohort Study over Two Decades |
title_fullStr | Maternal Vitamin D Status at Week 30 of Gestation and Offspring Cardio-Metabolic Health at 20 Years: A Prospective Cohort Study over Two Decades |
title_full_unstemmed | Maternal Vitamin D Status at Week 30 of Gestation and Offspring Cardio-Metabolic Health at 20 Years: A Prospective Cohort Study over Two Decades |
title_short | Maternal Vitamin D Status at Week 30 of Gestation and Offspring Cardio-Metabolic Health at 20 Years: A Prospective Cohort Study over Two Decades |
title_sort | maternal vitamin d status at week 30 of gestation and offspring cardio-metabolic health at 20 years: a prospective cohort study over two decades |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072548/ https://www.ncbi.nlm.nih.gov/pubmed/27764169 http://dx.doi.org/10.1371/journal.pone.0164758 |
work_keys_str_mv | AT rytterdorte maternalvitamindstatusatweek30ofgestationandoffspringcardiometabolichealthat20yearsaprospectivecohortstudyovertwodecades AT bechbodilhammer maternalvitamindstatusatweek30ofgestationandoffspringcardiometabolichealthat20yearsaprospectivecohortstudyovertwodecades AT halldorssonthorhalluringi maternalvitamindstatusatweek30ofgestationandoffspringcardiometabolichealthat20yearsaprospectivecohortstudyovertwodecades AT henriksentinebrink maternalvitamindstatusatweek30ofgestationandoffspringcardiometabolichealthat20yearsaprospectivecohortstudyovertwodecades AT grandstromcharlotta maternalvitamindstatusatweek30ofgestationandoffspringcardiometabolichealthat20yearsaprospectivecohortstudyovertwodecades AT cohenarieh maternalvitamindstatusatweek30ofgestationandoffspringcardiometabolichealthat20yearsaprospectivecohortstudyovertwodecades AT olsensjurdurfrodi maternalvitamindstatusatweek30ofgestationandoffspringcardiometabolichealthat20yearsaprospectivecohortstudyovertwodecades |