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Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning
Hippocampal development is thought to play a crucial role in the emergence of many forms of learning and memory, but ontogenetic changes in hippocampal activity during learning have not been examined thoroughly. We examined the ontogeny of hippocampal function by recording theta and single neuron ac...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072650/ https://www.ncbi.nlm.nih.gov/pubmed/27764172 http://dx.doi.org/10.1371/journal.pone.0164781 |
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author | Kim, Jangjin Goldsberry, Mary E. Harmon, Thomas C. Freeman, John H. |
author_facet | Kim, Jangjin Goldsberry, Mary E. Harmon, Thomas C. Freeman, John H. |
author_sort | Kim, Jangjin |
collection | PubMed |
description | Hippocampal development is thought to play a crucial role in the emergence of many forms of learning and memory, but ontogenetic changes in hippocampal activity during learning have not been examined thoroughly. We examined the ontogeny of hippocampal function by recording theta and single neuron activity from the dorsal hippocampal CA1 area while rat pups were trained in associative learning. Three different age groups [postnatal days (P)17-19, P21-23, and P24-26] were trained over six sessions using a tone conditioned stimulus (CS) and a periorbital stimulation unconditioned stimulus (US). Learning increased as a function of age, with the P21-23 and P24-26 groups learning faster than the P17-19 group. Age- and learning-related changes in both theta and single neuron activity were observed. CA1 pyramidal cells in the older age groups showed greater task-related activity than the P17-19 group during CS-US paired sessions. The proportion of trials with a significant theta (4–10 Hz) power change, the theta/delta ratio, and theta peak frequency also increased in an age-dependent manner. Finally, spike/theta phase-locking during the CS showed an age-related increase. The findings indicate substantial developmental changes in dorsal hippocampal function that may play a role in the ontogeny of learning and memory. |
format | Online Article Text |
id | pubmed-5072650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-50726502016-10-27 Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning Kim, Jangjin Goldsberry, Mary E. Harmon, Thomas C. Freeman, John H. PLoS One Research Article Hippocampal development is thought to play a crucial role in the emergence of many forms of learning and memory, but ontogenetic changes in hippocampal activity during learning have not been examined thoroughly. We examined the ontogeny of hippocampal function by recording theta and single neuron activity from the dorsal hippocampal CA1 area while rat pups were trained in associative learning. Three different age groups [postnatal days (P)17-19, P21-23, and P24-26] were trained over six sessions using a tone conditioned stimulus (CS) and a periorbital stimulation unconditioned stimulus (US). Learning increased as a function of age, with the P21-23 and P24-26 groups learning faster than the P17-19 group. Age- and learning-related changes in both theta and single neuron activity were observed. CA1 pyramidal cells in the older age groups showed greater task-related activity than the P17-19 group during CS-US paired sessions. The proportion of trials with a significant theta (4–10 Hz) power change, the theta/delta ratio, and theta peak frequency also increased in an age-dependent manner. Finally, spike/theta phase-locking during the CS showed an age-related increase. The findings indicate substantial developmental changes in dorsal hippocampal function that may play a role in the ontogeny of learning and memory. Public Library of Science 2016-10-20 /pmc/articles/PMC5072650/ /pubmed/27764172 http://dx.doi.org/10.1371/journal.pone.0164781 Text en © 2016 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kim, Jangjin Goldsberry, Mary E. Harmon, Thomas C. Freeman, John H. Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning |
title | Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning |
title_full | Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning |
title_fullStr | Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning |
title_full_unstemmed | Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning |
title_short | Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning |
title_sort | developmental changes in hippocampal ca1 single neuron firing and theta activity during associative learning |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072650/ https://www.ncbi.nlm.nih.gov/pubmed/27764172 http://dx.doi.org/10.1371/journal.pone.0164781 |
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