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Biodistribution of Idursulfase Formulated for Intrathecal Use (Idursulfase-IT) in Cynomolgus Monkeys after Intrathecal Lumbar Administration

Enzyme replacement therapy with intravenous idursulfase (recombinant iduronate-2-sulfatase) is approved for the treatment of Hunter syndrome. Intravenous administration does not, however, treat the neurological manifestations, due to its low central nervous system bioavailability. Using intrathecal-...

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Detalles Bibliográficos
Autores principales:	Chung, Jou-Ku, Brown, Eilish, Crooker, Bob, Palmieri, Kathleen J., McCauley, Thomas G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072681/ https://www.ncbi.nlm.nih.gov/pubmed/27764180 http://dx.doi.org/10.1371/journal.pone.0164765

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