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Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer
Enhancer of zeste homology 2 (EZH2) is the methyltransferase component of the polycomb repressive complex (PRC2) which represses gene transcription via histone H3 trimethylation at lysine 23 (H3K27me3). EZH2 activity has been linked with oncogenesis where it is thought to block expression of certain...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072726/ https://www.ncbi.nlm.nih.gov/pubmed/27764181 http://dx.doi.org/10.1371/journal.pone.0165005 |
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author | Lawrence, Cortney L. Baldwin, Albert S. |
author_facet | Lawrence, Cortney L. Baldwin, Albert S. |
author_sort | Lawrence, Cortney L. |
collection | PubMed |
description | Enhancer of zeste homology 2 (EZH2) is the methyltransferase component of the polycomb repressive complex (PRC2) which represses gene transcription via histone H3 trimethylation at lysine 23 (H3K27me3). EZH2 activity has been linked with oncogenesis where it is thought to block expression of certain tumor suppressors. Relative to a role in cancer, EZH2 functions to promote self-renewal and has been shown to be important for the tumor-initiating cell (TIC) phenotype in breast cancer. Recently a non-canonical role for EZH2 has been identified where it promotes transcriptional activation of certain genes. Here we show that EZH2, through a methyltransferase-independent mechanism, promotes the transcriptional activation of the non-canonical NF-κB subunit RelB to drive self-renewal and the TIC phenotype of triple-negative breast cancer cells. |
format | Online Article Text |
id | pubmed-5072726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-50727262016-10-27 Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer Lawrence, Cortney L. Baldwin, Albert S. PLoS One Research Article Enhancer of zeste homology 2 (EZH2) is the methyltransferase component of the polycomb repressive complex (PRC2) which represses gene transcription via histone H3 trimethylation at lysine 23 (H3K27me3). EZH2 activity has been linked with oncogenesis where it is thought to block expression of certain tumor suppressors. Relative to a role in cancer, EZH2 functions to promote self-renewal and has been shown to be important for the tumor-initiating cell (TIC) phenotype in breast cancer. Recently a non-canonical role for EZH2 has been identified where it promotes transcriptional activation of certain genes. Here we show that EZH2, through a methyltransferase-independent mechanism, promotes the transcriptional activation of the non-canonical NF-κB subunit RelB to drive self-renewal and the TIC phenotype of triple-negative breast cancer cells. Public Library of Science 2016-10-20 /pmc/articles/PMC5072726/ /pubmed/27764181 http://dx.doi.org/10.1371/journal.pone.0165005 Text en © 2016 Lawrence, Baldwin http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Lawrence, Cortney L. Baldwin, Albert S. Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer |
title | Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer |
title_full | Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer |
title_fullStr | Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer |
title_full_unstemmed | Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer |
title_short | Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer |
title_sort | non-canonical ezh2 transcriptionally activates relb in triple negative breast cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072726/ https://www.ncbi.nlm.nih.gov/pubmed/27764181 http://dx.doi.org/10.1371/journal.pone.0165005 |
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