An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4

The human HSV-1 and -2 are common pathogens of human diseases. Both host and viral factors are involved in HSV lytic infection, although detailed mechanisms remain elusive. By screening a chemical library of epigenetic regulation, we identified bromodomain-containing protein 4 (BRD4) as a critical p...

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Detalles Bibliográficos
Autores principales: Ren, Ke, Zhang, Wei, Chen, Xiaoqing, Ma, Yingyu, Dai, Yue, Fan, Yimei, Hou, Yayi, Tan, Ren Xiang, Li, Erguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072739/
https://www.ncbi.nlm.nih.gov/pubmed/27764245
http://dx.doi.org/10.1371/journal.ppat.1005950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072739/
https://www.ncbi.nlm.nih.gov/pubmed/27764245
http://dx.doi.org/10.1371/journal.ppat.1005950

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