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The prognostic value of regional lymph node metastases in patients of Guangdong Province, China with differentiated thyroid cancer: A multicenter retrospective clinical study
Although the prognostic value of nodal metastases in differentiated thyroid cancer remains controversial, it is of interest to evaluate and understand the different characteristics of predictive outcomes. A multicenter retrospective study was conducted in 215 untreated patients with differentiated t...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072939/ https://www.ncbi.nlm.nih.gov/pubmed/27741112 http://dx.doi.org/10.1097/MD.0000000000005034 |
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author | He, Lin-yun Wang, Wei-wei Ibrahima, Balde Alpha Han, Shuai Li, Zhou Cai, Zhai Chen, Miao-liang Chen, Bao-zhu Tan, Hui-shi Zeng, Hai-shan Dai, Xiao-li Zhou, Min-wei Zhang, Gang-qing Li, Guo-xin |
author_facet | He, Lin-yun Wang, Wei-wei Ibrahima, Balde Alpha Han, Shuai Li, Zhou Cai, Zhai Chen, Miao-liang Chen, Bao-zhu Tan, Hui-shi Zeng, Hai-shan Dai, Xiao-li Zhou, Min-wei Zhang, Gang-qing Li, Guo-xin |
author_sort | He, Lin-yun |
collection | PubMed |
description | Although the prognostic value of nodal metastases in differentiated thyroid cancer remains controversial, it is of interest to evaluate and understand the different characteristics of predictive outcomes. A multicenter retrospective study was conducted in 215 untreated patients with differentiated thyroid cancer from July 1997 to July 2015 in 4 medical centers of Guangdong Province. A total of 107 patients with nodal metastases (group A) were compared to 108 patients without metastases (group B). The 5-year disease-free survival (DFS), overall survival (OS), and postoperative complications in both groups were calculated. Variables predictive of DFS and OS were evaluated in group A. The group A had lower 5-year DFS (69.16%, 11 months) and shorter median time of recurrence than those in group B (87.96%, 8.5 months, respectively, P < 0.001). The incidence of temporary hypoparathyroidism in group A is lower; whereas higher incidence of temporary unilateral vocal cord palsy, permanent hypoparathyroidism, permanent unilateral vocal cord palsy, and bilateral vocal cord palsy in group A were observed. Both univariate and multivariate analyses in group A revealed that age, pathological tumor node metastasis (pTNM) stage, and histology were related to DFS (P < 0.05); while pTNM stage and histology were related to OS only in univariate analyses. Positive nodal metastases have significant prognostic value in patients with differentiated thyroid cancer in Guangdong, China and primarily reduce DFS. Moreover, patients with positive nodal metastases who are >45 years and have higher pTNM stage or follicular histology tend to have poor prognosis. Selective lymph node dissection with appropriate postoperative treatment and frequent follow-up should be accorded to these vulnerable groups of patients. |
format | Online Article Text |
id | pubmed-5072939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-50729392016-10-28 The prognostic value of regional lymph node metastases in patients of Guangdong Province, China with differentiated thyroid cancer: A multicenter retrospective clinical study He, Lin-yun Wang, Wei-wei Ibrahima, Balde Alpha Han, Shuai Li, Zhou Cai, Zhai Chen, Miao-liang Chen, Bao-zhu Tan, Hui-shi Zeng, Hai-shan Dai, Xiao-li Zhou, Min-wei Zhang, Gang-qing Li, Guo-xin Medicine (Baltimore) 4400 Although the prognostic value of nodal metastases in differentiated thyroid cancer remains controversial, it is of interest to evaluate and understand the different characteristics of predictive outcomes. A multicenter retrospective study was conducted in 215 untreated patients with differentiated thyroid cancer from July 1997 to July 2015 in 4 medical centers of Guangdong Province. A total of 107 patients with nodal metastases (group A) were compared to 108 patients without metastases (group B). The 5-year disease-free survival (DFS), overall survival (OS), and postoperative complications in both groups were calculated. Variables predictive of DFS and OS were evaluated in group A. The group A had lower 5-year DFS (69.16%, 11 months) and shorter median time of recurrence than those in group B (87.96%, 8.5 months, respectively, P < 0.001). The incidence of temporary hypoparathyroidism in group A is lower; whereas higher incidence of temporary unilateral vocal cord palsy, permanent hypoparathyroidism, permanent unilateral vocal cord palsy, and bilateral vocal cord palsy in group A were observed. Both univariate and multivariate analyses in group A revealed that age, pathological tumor node metastasis (pTNM) stage, and histology were related to DFS (P < 0.05); while pTNM stage and histology were related to OS only in univariate analyses. Positive nodal metastases have significant prognostic value in patients with differentiated thyroid cancer in Guangdong, China and primarily reduce DFS. Moreover, patients with positive nodal metastases who are >45 years and have higher pTNM stage or follicular histology tend to have poor prognosis. Selective lymph node dissection with appropriate postoperative treatment and frequent follow-up should be accorded to these vulnerable groups of patients. Wolters Kluwer Health 2016-10-14 /pmc/articles/PMC5072939/ /pubmed/27741112 http://dx.doi.org/10.1097/MD.0000000000005034 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0 |
spellingShingle | 4400 He, Lin-yun Wang, Wei-wei Ibrahima, Balde Alpha Han, Shuai Li, Zhou Cai, Zhai Chen, Miao-liang Chen, Bao-zhu Tan, Hui-shi Zeng, Hai-shan Dai, Xiao-li Zhou, Min-wei Zhang, Gang-qing Li, Guo-xin The prognostic value of regional lymph node metastases in patients of Guangdong Province, China with differentiated thyroid cancer: A multicenter retrospective clinical study |
title | The prognostic value of regional lymph node metastases in patients of Guangdong Province, China with differentiated thyroid cancer: A multicenter retrospective clinical study |
title_full | The prognostic value of regional lymph node metastases in patients of Guangdong Province, China with differentiated thyroid cancer: A multicenter retrospective clinical study |
title_fullStr | The prognostic value of regional lymph node metastases in patients of Guangdong Province, China with differentiated thyroid cancer: A multicenter retrospective clinical study |
title_full_unstemmed | The prognostic value of regional lymph node metastases in patients of Guangdong Province, China with differentiated thyroid cancer: A multicenter retrospective clinical study |
title_short | The prognostic value of regional lymph node metastases in patients of Guangdong Province, China with differentiated thyroid cancer: A multicenter retrospective clinical study |
title_sort | prognostic value of regional lymph node metastases in patients of guangdong province, china with differentiated thyroid cancer: a multicenter retrospective clinical study |
topic | 4400 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072939/ https://www.ncbi.nlm.nih.gov/pubmed/27741112 http://dx.doi.org/10.1097/MD.0000000000005034 |
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