Mitochondrial Quality Control in Cardiac Diseases

Disruption of mitochondrial homeostasis is a hallmark of cardiac diseases. Therefore, maintenance of mitochondrial integrity through different surveillance mechanisms is critical for cardiomyocyte survival. In this review, we discuss the most recent findings on the central role of mitochondrial qual...

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Detalles Bibliográficos
Autores principales: Campos, Juliane C., Bozi, Luiz H. M., Bechara, Luiz R. G., Lima, Vanessa M., Ferreira, Julio C. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073139/
https://www.ncbi.nlm.nih.gov/pubmed/27818636
http://dx.doi.org/10.3389/fphys.2016.00479
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author Campos, Juliane C.
Bozi, Luiz H. M.
Bechara, Luiz R. G.
Lima, Vanessa M.
Ferreira, Julio C. B.
author_facet Campos, Juliane C.
Bozi, Luiz H. M.
Bechara, Luiz R. G.
Lima, Vanessa M.
Ferreira, Julio C. B.
author_sort Campos, Juliane C.
collection PubMed
description Disruption of mitochondrial homeostasis is a hallmark of cardiac diseases. Therefore, maintenance of mitochondrial integrity through different surveillance mechanisms is critical for cardiomyocyte survival. In this review, we discuss the most recent findings on the central role of mitochondrial quality control processes including regulation of mitochondrial redox balance, aldehyde metabolism, proteostasis, dynamics, and clearance in cardiac diseases, highlighting their potential as therapeutic targets.
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spelling pubmed-50731392016-11-04 Mitochondrial Quality Control in Cardiac Diseases Campos, Juliane C. Bozi, Luiz H. M. Bechara, Luiz R. G. Lima, Vanessa M. Ferreira, Julio C. B. Front Physiol Physiology Disruption of mitochondrial homeostasis is a hallmark of cardiac diseases. Therefore, maintenance of mitochondrial integrity through different surveillance mechanisms is critical for cardiomyocyte survival. In this review, we discuss the most recent findings on the central role of mitochondrial quality control processes including regulation of mitochondrial redox balance, aldehyde metabolism, proteostasis, dynamics, and clearance in cardiac diseases, highlighting their potential as therapeutic targets. Frontiers Media S.A. 2016-10-21 /pmc/articles/PMC5073139/ /pubmed/27818636 http://dx.doi.org/10.3389/fphys.2016.00479 Text en Copyright © 2016 Campos, Bozi, Bechara, Lima and Ferreira. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Campos, Juliane C.
Bozi, Luiz H. M.
Bechara, Luiz R. G.
Lima, Vanessa M.
Ferreira, Julio C. B.
Mitochondrial Quality Control in Cardiac Diseases
title Mitochondrial Quality Control in Cardiac Diseases
title_full Mitochondrial Quality Control in Cardiac Diseases
title_fullStr Mitochondrial Quality Control in Cardiac Diseases
title_full_unstemmed Mitochondrial Quality Control in Cardiac Diseases
title_short Mitochondrial Quality Control in Cardiac Diseases
title_sort mitochondrial quality control in cardiac diseases
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073139/
https://www.ncbi.nlm.nih.gov/pubmed/27818636
http://dx.doi.org/10.3389/fphys.2016.00479
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