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Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
Influenza antigenic and genetic characterisation data are crucial for influenza vaccine composition decision making. Previously, aggregate data were reported to the European Centre for Disease Prevention and Control by European Union/European Economic Area (EU/EEA) countries. A system for collecting...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073191/ https://www.ncbi.nlm.nih.gov/pubmed/27762211 http://dx.doi.org/10.2807/1560-7917.ES.2016.21.41.30370 |
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author | Broberg, Eeva Hungnes, Olav Schweiger, Brunhilde Prosenc, Katarina Daniels, Rod Guiomar, Raquel Ikonen, Niina Kossyvakis, Athanasios Pozo, Francisco Puzelli, Simona Thomas, Isabelle Waters, Allison Wiman, Åsa Meijer, Adam |
author_facet | Broberg, Eeva Hungnes, Olav Schweiger, Brunhilde Prosenc, Katarina Daniels, Rod Guiomar, Raquel Ikonen, Niina Kossyvakis, Athanasios Pozo, Francisco Puzelli, Simona Thomas, Isabelle Waters, Allison Wiman, Åsa Meijer, Adam |
author_sort | Broberg, Eeva |
collection | PubMed |
description | Influenza antigenic and genetic characterisation data are crucial for influenza vaccine composition decision making. Previously, aggregate data were reported to the European Centre for Disease Prevention and Control by European Union/European Economic Area (EU/EEA) countries. A system for collecting case-specific influenza antigenic and genetic characterisation data was established for the 2013/14 influenza season. In a pilot study, 11 EU/EEA countries reported through the new mechanism. We demonstrated feasibility of reporting strain-based antigenic and genetic data and ca 10% of influenza virus-positive specimens were selected for further characterisation. Proportions of characterised virus (sub)types were similar to influenza virus circulation levels. The main genetic clades were represented by A/StPetersburg/27/2011(H1N1)pdm09 and A/Texas/50/2012(H3N2). A(H1N1)pdm09 viruses were more prevalent in age groups (by years) < 1 (65%; p = 0.0111), 20–39 (50%; p = 0.0046) and 40–64 (55%; p = 0.00001) while A(H3N2) viruses were most prevalent in those ≥ 65 years (62%*; p = 0.0012). Hospitalised patients in the age groups 6–19 years (67%; p = 0.0494) and ≥ 65 years (52%; p = 0.0005) were more frequently infected by A/Texas/50/2012 A(H3N2)-like viruses compared with hospitalised cases in other age groups. Strain-based reporting enabled deeper understanding of influenza virus circulation among hospitalised patients and substantially improved the reporting of virus characterisation data. Therefore, strain-based reporting of readily available data is recommended to all reporting countries within the EU/EEA. |
format | Online Article Text |
id | pubmed-5073191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | European Centre for Disease Prevention and Control (ECDC) |
record_format | MEDLINE/PubMed |
spelling | pubmed-50731912016-10-21 Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14 Broberg, Eeva Hungnes, Olav Schweiger, Brunhilde Prosenc, Katarina Daniels, Rod Guiomar, Raquel Ikonen, Niina Kossyvakis, Athanasios Pozo, Francisco Puzelli, Simona Thomas, Isabelle Waters, Allison Wiman, Åsa Meijer, Adam Euro Surveill Surveillance and Outbreak Report Influenza antigenic and genetic characterisation data are crucial for influenza vaccine composition decision making. Previously, aggregate data were reported to the European Centre for Disease Prevention and Control by European Union/European Economic Area (EU/EEA) countries. A system for collecting case-specific influenza antigenic and genetic characterisation data was established for the 2013/14 influenza season. In a pilot study, 11 EU/EEA countries reported through the new mechanism. We demonstrated feasibility of reporting strain-based antigenic and genetic data and ca 10% of influenza virus-positive specimens were selected for further characterisation. Proportions of characterised virus (sub)types were similar to influenza virus circulation levels. The main genetic clades were represented by A/StPetersburg/27/2011(H1N1)pdm09 and A/Texas/50/2012(H3N2). A(H1N1)pdm09 viruses were more prevalent in age groups (by years) < 1 (65%; p = 0.0111), 20–39 (50%; p = 0.0046) and 40–64 (55%; p = 0.00001) while A(H3N2) viruses were most prevalent in those ≥ 65 years (62%*; p = 0.0012). Hospitalised patients in the age groups 6–19 years (67%; p = 0.0494) and ≥ 65 years (52%; p = 0.0005) were more frequently infected by A/Texas/50/2012 A(H3N2)-like viruses compared with hospitalised cases in other age groups. Strain-based reporting enabled deeper understanding of influenza virus circulation among hospitalised patients and substantially improved the reporting of virus characterisation data. Therefore, strain-based reporting of readily available data is recommended to all reporting countries within the EU/EEA. European Centre for Disease Prevention and Control (ECDC) 2016-10-13 /pmc/articles/PMC5073191/ /pubmed/27762211 http://dx.doi.org/10.2807/1560-7917.ES.2016.21.41.30370 Text en This article is copyright of The Authors, 2016. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
spellingShingle | Surveillance and Outbreak Report Broberg, Eeva Hungnes, Olav Schweiger, Brunhilde Prosenc, Katarina Daniels, Rod Guiomar, Raquel Ikonen, Niina Kossyvakis, Athanasios Pozo, Francisco Puzelli, Simona Thomas, Isabelle Waters, Allison Wiman, Åsa Meijer, Adam Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14 |
title | Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14 |
title_full | Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14 |
title_fullStr | Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14 |
title_full_unstemmed | Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14 |
title_short | Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14 |
title_sort | improving influenza virological surveillance in europe: strain-based reporting of antigenic and genetic characterisation data, 11 european countries, influenza season 2013/14 |
topic | Surveillance and Outbreak Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073191/ https://www.ncbi.nlm.nih.gov/pubmed/27762211 http://dx.doi.org/10.2807/1560-7917.ES.2016.21.41.30370 |
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