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Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14

Influenza antigenic and genetic characterisation data are crucial for influenza vaccine composition decision making. Previously, aggregate data were reported to the European Centre for Disease Prevention and Control by European Union/European Economic Area (EU/EEA) countries. A system for collecting...

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Autores principales: Broberg, Eeva, Hungnes, Olav, Schweiger, Brunhilde, Prosenc, Katarina, Daniels, Rod, Guiomar, Raquel, Ikonen, Niina, Kossyvakis, Athanasios, Pozo, Francisco, Puzelli, Simona, Thomas, Isabelle, Waters, Allison, Wiman, Åsa, Meijer, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073191/
https://www.ncbi.nlm.nih.gov/pubmed/27762211
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.41.30370
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author Broberg, Eeva
Hungnes, Olav
Schweiger, Brunhilde
Prosenc, Katarina
Daniels, Rod
Guiomar, Raquel
Ikonen, Niina
Kossyvakis, Athanasios
Pozo, Francisco
Puzelli, Simona
Thomas, Isabelle
Waters, Allison
Wiman, Åsa
Meijer, Adam
author_facet Broberg, Eeva
Hungnes, Olav
Schweiger, Brunhilde
Prosenc, Katarina
Daniels, Rod
Guiomar, Raquel
Ikonen, Niina
Kossyvakis, Athanasios
Pozo, Francisco
Puzelli, Simona
Thomas, Isabelle
Waters, Allison
Wiman, Åsa
Meijer, Adam
author_sort Broberg, Eeva
collection PubMed
description Influenza antigenic and genetic characterisation data are crucial for influenza vaccine composition decision making. Previously, aggregate data were reported to the European Centre for Disease Prevention and Control by European Union/European Economic Area (EU/EEA) countries. A system for collecting case-specific influenza antigenic and genetic characterisation data was established for the 2013/14 influenza season. In a pilot study, 11 EU/EEA countries reported through the new mechanism. We demonstrated feasibility of reporting strain-based antigenic and genetic data and ca 10% of influenza virus-positive specimens were selected for further characterisation. Proportions of characterised virus (sub)types were similar to influenza virus circulation levels. The main genetic clades were represented by A/StPetersburg/27/2011(H1N1)pdm09 and A/Texas/50/2012(H3N2). A(H1N1)pdm09 viruses were more prevalent in age groups (by years) < 1 (65%; p = 0.0111), 20–39 (50%; p = 0.0046) and 40–64 (55%; p = 0.00001) while A(H3N2) viruses were most prevalent in those ≥ 65 years (62%*; p = 0.0012). Hospitalised patients in the age groups 6–19 years (67%; p = 0.0494) and ≥ 65 years (52%; p = 0.0005) were more frequently infected by A/Texas/50/2012 A(H3N2)-like viruses compared with hospitalised cases in other age groups. Strain-based reporting enabled deeper understanding of influenza virus circulation among hospitalised patients and substantially improved the reporting of virus characterisation data. Therefore, strain-based reporting of readily available data is recommended to all reporting countries within the EU/EEA.
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spelling pubmed-50731912016-10-21 Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14 Broberg, Eeva Hungnes, Olav Schweiger, Brunhilde Prosenc, Katarina Daniels, Rod Guiomar, Raquel Ikonen, Niina Kossyvakis, Athanasios Pozo, Francisco Puzelli, Simona Thomas, Isabelle Waters, Allison Wiman, Åsa Meijer, Adam Euro Surveill Surveillance and Outbreak Report Influenza antigenic and genetic characterisation data are crucial for influenza vaccine composition decision making. Previously, aggregate data were reported to the European Centre for Disease Prevention and Control by European Union/European Economic Area (EU/EEA) countries. A system for collecting case-specific influenza antigenic and genetic characterisation data was established for the 2013/14 influenza season. In a pilot study, 11 EU/EEA countries reported through the new mechanism. We demonstrated feasibility of reporting strain-based antigenic and genetic data and ca 10% of influenza virus-positive specimens were selected for further characterisation. Proportions of characterised virus (sub)types were similar to influenza virus circulation levels. The main genetic clades were represented by A/StPetersburg/27/2011(H1N1)pdm09 and A/Texas/50/2012(H3N2). A(H1N1)pdm09 viruses were more prevalent in age groups (by years) < 1 (65%; p = 0.0111), 20–39 (50%; p = 0.0046) and 40–64 (55%; p = 0.00001) while A(H3N2) viruses were most prevalent in those ≥ 65 years (62%*; p = 0.0012). Hospitalised patients in the age groups 6–19 years (67%; p = 0.0494) and ≥ 65 years (52%; p = 0.0005) were more frequently infected by A/Texas/50/2012 A(H3N2)-like viruses compared with hospitalised cases in other age groups. Strain-based reporting enabled deeper understanding of influenza virus circulation among hospitalised patients and substantially improved the reporting of virus characterisation data. Therefore, strain-based reporting of readily available data is recommended to all reporting countries within the EU/EEA. European Centre for Disease Prevention and Control (ECDC) 2016-10-13 /pmc/articles/PMC5073191/ /pubmed/27762211 http://dx.doi.org/10.2807/1560-7917.ES.2016.21.41.30370 Text en This article is copyright of The Authors, 2016. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Surveillance and Outbreak Report
Broberg, Eeva
Hungnes, Olav
Schweiger, Brunhilde
Prosenc, Katarina
Daniels, Rod
Guiomar, Raquel
Ikonen, Niina
Kossyvakis, Athanasios
Pozo, Francisco
Puzelli, Simona
Thomas, Isabelle
Waters, Allison
Wiman, Åsa
Meijer, Adam
Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
title Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
title_full Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
title_fullStr Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
title_full_unstemmed Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
title_short Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
title_sort improving influenza virological surveillance in europe: strain-based reporting of antigenic and genetic characterisation data, 11 european countries, influenza season 2013/14
topic Surveillance and Outbreak Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073191/
https://www.ncbi.nlm.nih.gov/pubmed/27762211
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.41.30370
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