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Impact of different antithrombotics on the microcirculation and viability of perforator-based ischaemic skin flaps in a small animal model
The effects of antithrombotic drugs on random and free flap survival have been investigated in the past, but the experimental and clinical results are not in agreement. A perforator-based critical ischaemia model was used to evaluate the effects of different perioperatively administered pharmaceutic...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073281/ https://www.ncbi.nlm.nih.gov/pubmed/27767060 http://dx.doi.org/10.1038/srep35833 |
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author | Fichter, Andreas M. Ritschl, Lucas M. Robitzky, Luisa K. Wagenpfeil, Stefan Mitchell, David A. Wolff, Klaus-Dietrich Mücke, Thomas |
author_facet | Fichter, Andreas M. Ritschl, Lucas M. Robitzky, Luisa K. Wagenpfeil, Stefan Mitchell, David A. Wolff, Klaus-Dietrich Mücke, Thomas |
author_sort | Fichter, Andreas M. |
collection | PubMed |
description | The effects of antithrombotic drugs on random and free flap survival have been investigated in the past, but the experimental and clinical results are not in agreement. A perforator-based critical ischaemia model was used to evaluate the effects of different perioperatively administered pharmaceutical agents on tissue ischaemia and to assess the potential additional haemorheological or vasodilative effects of antithrombotics on flap microcirculation. Combined laser Doppler flowmetry and remission spectroscopy revealed an increase in certain microcirculation parameters in most groups in comparison with saline controls, and these changes correlated with flap survival. Clopidogrel and hirudin significantly improved the amount of viable flap tissue in comparison with controls, while unfractioned heparin had a negative effect on flap survival. Low molecular weight heparin, aspirin, pentoxifylline, and hydroxyethyl starch had no impact on the amount of viable flap tissue. A higher complication rate was observed in all experimental groups, but only clopidogrel had a negative impact on the flap viability. Our results add to the body of evidence supporting the conclusion that perioperative antithrombotic treatment improves flap survival. Clopidogrel and hirudin are effective pharmacological agents that significantly increased the viability of perforator-based skin flaps in rats, but at a higher risk of postoperative bleeding. |
format | Online Article Text |
id | pubmed-5073281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50732812016-10-26 Impact of different antithrombotics on the microcirculation and viability of perforator-based ischaemic skin flaps in a small animal model Fichter, Andreas M. Ritschl, Lucas M. Robitzky, Luisa K. Wagenpfeil, Stefan Mitchell, David A. Wolff, Klaus-Dietrich Mücke, Thomas Sci Rep Article The effects of antithrombotic drugs on random and free flap survival have been investigated in the past, but the experimental and clinical results are not in agreement. A perforator-based critical ischaemia model was used to evaluate the effects of different perioperatively administered pharmaceutical agents on tissue ischaemia and to assess the potential additional haemorheological or vasodilative effects of antithrombotics on flap microcirculation. Combined laser Doppler flowmetry and remission spectroscopy revealed an increase in certain microcirculation parameters in most groups in comparison with saline controls, and these changes correlated with flap survival. Clopidogrel and hirudin significantly improved the amount of viable flap tissue in comparison with controls, while unfractioned heparin had a negative effect on flap survival. Low molecular weight heparin, aspirin, pentoxifylline, and hydroxyethyl starch had no impact on the amount of viable flap tissue. A higher complication rate was observed in all experimental groups, but only clopidogrel had a negative impact on the flap viability. Our results add to the body of evidence supporting the conclusion that perioperative antithrombotic treatment improves flap survival. Clopidogrel and hirudin are effective pharmacological agents that significantly increased the viability of perforator-based skin flaps in rats, but at a higher risk of postoperative bleeding. Nature Publishing Group 2016-10-21 /pmc/articles/PMC5073281/ /pubmed/27767060 http://dx.doi.org/10.1038/srep35833 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Fichter, Andreas M. Ritschl, Lucas M. Robitzky, Luisa K. Wagenpfeil, Stefan Mitchell, David A. Wolff, Klaus-Dietrich Mücke, Thomas Impact of different antithrombotics on the microcirculation and viability of perforator-based ischaemic skin flaps in a small animal model |
title | Impact of different antithrombotics on the microcirculation and viability of perforator-based ischaemic skin flaps in a small animal model |
title_full | Impact of different antithrombotics on the microcirculation and viability of perforator-based ischaemic skin flaps in a small animal model |
title_fullStr | Impact of different antithrombotics on the microcirculation and viability of perforator-based ischaemic skin flaps in a small animal model |
title_full_unstemmed | Impact of different antithrombotics on the microcirculation and viability of perforator-based ischaemic skin flaps in a small animal model |
title_short | Impact of different antithrombotics on the microcirculation and viability of perforator-based ischaemic skin flaps in a small animal model |
title_sort | impact of different antithrombotics on the microcirculation and viability of perforator-based ischaemic skin flaps in a small animal model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073281/ https://www.ncbi.nlm.nih.gov/pubmed/27767060 http://dx.doi.org/10.1038/srep35833 |
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