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Tumor-targeted delivery of a C-terminally truncated FADD (N-FADD) significantly suppresses the B16F10 melanoma via enhancing apoptosis

Fas-associated protein with death domain (FADD), a pivotal adaptor protein transmitting apoptotic signals, is indispensable for the induction of extrinsic apoptosis. However, overexpression of FADD can form large, filamentous aggregates, termed death effector filaments (DEFs) by self-association and...

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Detalles Bibliográficos
Autores principales:	Yang, Yun-Wen, Zhang, Chun-Mei, Huang, Xian-Jie, Zhang, Xiao-Xin, Zhang, Lin-Kai, Li, Jia-Huang, Hua, Zi-Chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073321/ https://www.ncbi.nlm.nih.gov/pubmed/27767039 http://dx.doi.org/10.1038/srep34178

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