Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells

Sirtuin-1 (SIRT1) and SIRT6, NAD(+)-dependent Class III protein deacetylases, are putative anti-aging enzymes, down-regulated in patients with chronic obstructive pulmonary disease (COPD), which is characterized by the accelerated ageing of the lung and associated with increased oxidative stress. He...

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Detalles Bibliográficos
Autores principales: Baker, J. R., Vuppusetty, C., Colley, T., Papaioannou, Andriana I., Fenwick, P., Donnelly, Louise, Ito, K., Barnes, P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073335/
https://www.ncbi.nlm.nih.gov/pubmed/27767101
http://dx.doi.org/10.1038/srep35871

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