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Changes seen on computed tomography of the chest in mildly symptomatic adult patients with sickle cell disease
OBJECTIVE: To describe and quantify the main changes seen on computed tomography of the chest in mildly symptomatic adult patients with sickle cell disease, as well as to evaluate the radiologist accuracy in determining the type of hemoglobinopathy. MATERIALS AND METHODS: A prospective study involvi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Colégio Brasileiro de Radiologia e Diagnóstico por
Imagem
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073386/ https://www.ncbi.nlm.nih.gov/pubmed/27777473 http://dx.doi.org/10.1590/0100-3984.2015.0111 |
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author | Alves, Ursula David Lopes, Agnaldo José Maioli, Maria Christina Paixão Soares, Andrea Ribeiro de Melo, Pedro Lopes Mogami, Roberto |
author_facet | Alves, Ursula David Lopes, Agnaldo José Maioli, Maria Christina Paixão Soares, Andrea Ribeiro de Melo, Pedro Lopes Mogami, Roberto |
author_sort | Alves, Ursula David |
collection | PubMed |
description | OBJECTIVE: To describe and quantify the main changes seen on computed tomography of the chest in mildly symptomatic adult patients with sickle cell disease, as well as to evaluate the radiologist accuracy in determining the type of hemoglobinopathy. MATERIALS AND METHODS: A prospective study involving 44 adult patients with sickle cell disease who underwent inspiration and expiration computed tomography of the chest. The frequency of tomography findings and the extent of involvement are reported. We also calculated radiologist accuracy in determining the type of hemoglobinopathy by analyzing the pulmonary alterations and morphology of the spleen. RESULTS: The changes found on computed tomography scans, in descending order of frequency, were as follows: fibrotic opacities (81.8%); mosaic attenuation (56.8%); architectural distortion (31.8%); cardiomegaly (25.0%); lobar volume reduction (18.2%); and increased caliber of peripheral pulmonary arteries (9.1%). For most of the findings, the involvement was considered mild, five or fewer lung segments being affected. The accuracy in determining the type of hemoglobinopathy (HbSS group versus not HbSS group) was 72.7%. CONCLUSION: In adult patients with sickle cell disease, the main tomography findings reflect fibrotic changes. In addition, computed tomography can be helpful in differentiating among hemoglobinopathies. |
format | Online Article Text |
id | pubmed-5073386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Colégio Brasileiro de Radiologia e Diagnóstico por
Imagem |
record_format | MEDLINE/PubMed |
spelling | pubmed-50733862016-10-24 Changes seen on computed tomography of the chest in mildly symptomatic adult patients with sickle cell disease Alves, Ursula David Lopes, Agnaldo José Maioli, Maria Christina Paixão Soares, Andrea Ribeiro de Melo, Pedro Lopes Mogami, Roberto Radiol Bras Original Articles OBJECTIVE: To describe and quantify the main changes seen on computed tomography of the chest in mildly symptomatic adult patients with sickle cell disease, as well as to evaluate the radiologist accuracy in determining the type of hemoglobinopathy. MATERIALS AND METHODS: A prospective study involving 44 adult patients with sickle cell disease who underwent inspiration and expiration computed tomography of the chest. The frequency of tomography findings and the extent of involvement are reported. We also calculated radiologist accuracy in determining the type of hemoglobinopathy by analyzing the pulmonary alterations and morphology of the spleen. RESULTS: The changes found on computed tomography scans, in descending order of frequency, were as follows: fibrotic opacities (81.8%); mosaic attenuation (56.8%); architectural distortion (31.8%); cardiomegaly (25.0%); lobar volume reduction (18.2%); and increased caliber of peripheral pulmonary arteries (9.1%). For most of the findings, the involvement was considered mild, five or fewer lung segments being affected. The accuracy in determining the type of hemoglobinopathy (HbSS group versus not HbSS group) was 72.7%. CONCLUSION: In adult patients with sickle cell disease, the main tomography findings reflect fibrotic changes. In addition, computed tomography can be helpful in differentiating among hemoglobinopathies. Colégio Brasileiro de Radiologia e Diagnóstico por Imagem 2016 /pmc/articles/PMC5073386/ /pubmed/27777473 http://dx.doi.org/10.1590/0100-3984.2015.0111 Text en © Colégio Brasileiro de Radiologia e Diagnóstico por Imagem http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Alves, Ursula David Lopes, Agnaldo José Maioli, Maria Christina Paixão Soares, Andrea Ribeiro de Melo, Pedro Lopes Mogami, Roberto Changes seen on computed tomography of the chest in mildly symptomatic adult patients with sickle cell disease |
title | Changes seen on computed tomography of the chest in mildly
symptomatic adult patients with sickle cell disease |
title_full | Changes seen on computed tomography of the chest in mildly
symptomatic adult patients with sickle cell disease |
title_fullStr | Changes seen on computed tomography of the chest in mildly
symptomatic adult patients with sickle cell disease |
title_full_unstemmed | Changes seen on computed tomography of the chest in mildly
symptomatic adult patients with sickle cell disease |
title_short | Changes seen on computed tomography of the chest in mildly
symptomatic adult patients with sickle cell disease |
title_sort | changes seen on computed tomography of the chest in mildly
symptomatic adult patients with sickle cell disease |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073386/ https://www.ncbi.nlm.nih.gov/pubmed/27777473 http://dx.doi.org/10.1590/0100-3984.2015.0111 |
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