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Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure
OBJECTIVE: To investigate whether relationships exist among vitamin D, type 2 diabetes mellitus (T2DM), and blood pressure in Trinidadian subjects with T2DM. RESEARCH DESIGN AND METHODS: This was a case–controlled study to determine if vitamin D levels were lower in patients with T2DM. After data an...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073486/ https://www.ncbi.nlm.nih.gov/pubmed/27843555 http://dx.doi.org/10.1136/bmjdrc-2016-000285 |
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author | Nayak, Shivananda Bijoor Ramnanansingh, Terry Gavaskar |
author_facet | Nayak, Shivananda Bijoor Ramnanansingh, Terry Gavaskar |
author_sort | Nayak, Shivananda Bijoor |
collection | PubMed |
description | OBJECTIVE: To investigate whether relationships exist among vitamin D, type 2 diabetes mellitus (T2DM), and blood pressure in Trinidadian subjects with T2DM. RESEARCH DESIGN AND METHODS: This was a case–controlled study to determine if vitamin D levels were lower in patients with T2DM. After data analysis, an exploratory hypothesis of vitamin D relationship to systolic blood pressure (SBP) was developed. Plasma calcifediol (25(OH)D) concentrations were used as a measurement for vitamin D levels and were determined by ELISA. Cholesterol levels were measured by an automated dry chemistry analyzer and blood pressure was measured using an automatic blood pressure monitor. RESULTS: There was no significant difference (p=0.139, n=76) in 25(OH)D levels between patients with T2DM and controls. Subjects with SBP above 130 mm Hg were 8 times more likely to have a 25(OH)D plasma concentration above 25 ng/mL (OR 7.9 (2.2 to 28.7)), and were 5 times (OR 4.7 (1.7 to 15.1)) more likely to have a 25(OH)D plasma concentration above 30 ng/mL (OR 7.5 (2.3–24.2)). Vitamin D levels moderately and positively correlated with SBP (r(s)=0.38, p=0.001). CONCLUSIONS: There was no significant difference in the 25(OH)D levels between patients with T2DM and controls (p=0.139). Patients with SBP under 130 mm Hg were 8 times more likely to have a vitamin D level above 25 ng/mL (OR 7.9 (2.2 to 28.7)). Further investigations are required to examine the relationship between vitamin D and SBP. |
format | Online Article Text |
id | pubmed-5073486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50734862016-11-14 Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure Nayak, Shivananda Bijoor Ramnanansingh, Terry Gavaskar BMJ Open Diabetes Res Care Cardiovascular and Metabolic Risk OBJECTIVE: To investigate whether relationships exist among vitamin D, type 2 diabetes mellitus (T2DM), and blood pressure in Trinidadian subjects with T2DM. RESEARCH DESIGN AND METHODS: This was a case–controlled study to determine if vitamin D levels were lower in patients with T2DM. After data analysis, an exploratory hypothesis of vitamin D relationship to systolic blood pressure (SBP) was developed. Plasma calcifediol (25(OH)D) concentrations were used as a measurement for vitamin D levels and were determined by ELISA. Cholesterol levels were measured by an automated dry chemistry analyzer and blood pressure was measured using an automatic blood pressure monitor. RESULTS: There was no significant difference (p=0.139, n=76) in 25(OH)D levels between patients with T2DM and controls. Subjects with SBP above 130 mm Hg were 8 times more likely to have a 25(OH)D plasma concentration above 25 ng/mL (OR 7.9 (2.2 to 28.7)), and were 5 times (OR 4.7 (1.7 to 15.1)) more likely to have a 25(OH)D plasma concentration above 30 ng/mL (OR 7.5 (2.3–24.2)). Vitamin D levels moderately and positively correlated with SBP (r(s)=0.38, p=0.001). CONCLUSIONS: There was no significant difference in the 25(OH)D levels between patients with T2DM and controls (p=0.139). Patients with SBP under 130 mm Hg were 8 times more likely to have a vitamin D level above 25 ng/mL (OR 7.9 (2.2 to 28.7)). Further investigations are required to examine the relationship between vitamin D and SBP. BMJ Publishing Group 2016-10-10 /pmc/articles/PMC5073486/ /pubmed/27843555 http://dx.doi.org/10.1136/bmjdrc-2016-000285 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Cardiovascular and Metabolic Risk Nayak, Shivananda Bijoor Ramnanansingh, Terry Gavaskar Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure |
title | Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure |
title_full | Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure |
title_fullStr | Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure |
title_full_unstemmed | Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure |
title_short | Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure |
title_sort | evaluation of vitamin d relationship with type 2 diabetes and systolic blood pressure |
topic | Cardiovascular and Metabolic Risk |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073486/ https://www.ncbi.nlm.nih.gov/pubmed/27843555 http://dx.doi.org/10.1136/bmjdrc-2016-000285 |
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