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Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure

OBJECTIVE: To investigate whether relationships exist among vitamin D, type 2 diabetes mellitus (T2DM), and blood pressure in Trinidadian subjects with T2DM. RESEARCH DESIGN AND METHODS: This was a case–controlled study to determine if vitamin D levels were lower in patients with T2DM. After data an...

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Autores principales: Nayak, Shivananda Bijoor, Ramnanansingh, Terry Gavaskar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073486/
https://www.ncbi.nlm.nih.gov/pubmed/27843555
http://dx.doi.org/10.1136/bmjdrc-2016-000285
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author Nayak, Shivananda Bijoor
Ramnanansingh, Terry Gavaskar
author_facet Nayak, Shivananda Bijoor
Ramnanansingh, Terry Gavaskar
author_sort Nayak, Shivananda Bijoor
collection PubMed
description OBJECTIVE: To investigate whether relationships exist among vitamin D, type 2 diabetes mellitus (T2DM), and blood pressure in Trinidadian subjects with T2DM. RESEARCH DESIGN AND METHODS: This was a case–controlled study to determine if vitamin D levels were lower in patients with T2DM. After data analysis, an exploratory hypothesis of vitamin D relationship to systolic blood pressure (SBP) was developed. Plasma calcifediol (25(OH)D) concentrations were used as a measurement for vitamin D levels and were determined by ELISA. Cholesterol levels were measured by an automated dry chemistry analyzer and blood pressure was measured using an automatic blood pressure monitor. RESULTS: There was no significant difference (p=0.139, n=76) in 25(OH)D levels between patients with T2DM and controls. Subjects with SBP above 130 mm Hg were 8 times more likely to have a 25(OH)D plasma concentration above 25 ng/mL (OR 7.9 (2.2 to 28.7)), and were 5 times (OR 4.7 (1.7 to 15.1)) more likely to have a 25(OH)D plasma concentration above 30 ng/mL (OR 7.5 (2.3–24.2)). Vitamin D levels moderately and positively correlated with SBP (r(s)=0.38, p=0.001). CONCLUSIONS: There was no significant difference in the 25(OH)D levels between patients with T2DM and controls (p=0.139). Patients with SBP under 130 mm Hg were 8 times more likely to have a vitamin D level above 25 ng/mL (OR 7.9 (2.2 to 28.7)). Further investigations are required to examine the relationship between vitamin D and SBP.
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spelling pubmed-50734862016-11-14 Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure Nayak, Shivananda Bijoor Ramnanansingh, Terry Gavaskar BMJ Open Diabetes Res Care Cardiovascular and Metabolic Risk OBJECTIVE: To investigate whether relationships exist among vitamin D, type 2 diabetes mellitus (T2DM), and blood pressure in Trinidadian subjects with T2DM. RESEARCH DESIGN AND METHODS: This was a case–controlled study to determine if vitamin D levels were lower in patients with T2DM. After data analysis, an exploratory hypothesis of vitamin D relationship to systolic blood pressure (SBP) was developed. Plasma calcifediol (25(OH)D) concentrations were used as a measurement for vitamin D levels and were determined by ELISA. Cholesterol levels were measured by an automated dry chemistry analyzer and blood pressure was measured using an automatic blood pressure monitor. RESULTS: There was no significant difference (p=0.139, n=76) in 25(OH)D levels between patients with T2DM and controls. Subjects with SBP above 130 mm Hg were 8 times more likely to have a 25(OH)D plasma concentration above 25 ng/mL (OR 7.9 (2.2 to 28.7)), and were 5 times (OR 4.7 (1.7 to 15.1)) more likely to have a 25(OH)D plasma concentration above 30 ng/mL (OR 7.5 (2.3–24.2)). Vitamin D levels moderately and positively correlated with SBP (r(s)=0.38, p=0.001). CONCLUSIONS: There was no significant difference in the 25(OH)D levels between patients with T2DM and controls (p=0.139). Patients with SBP under 130 mm Hg were 8 times more likely to have a vitamin D level above 25 ng/mL (OR 7.9 (2.2 to 28.7)). Further investigations are required to examine the relationship between vitamin D and SBP. BMJ Publishing Group 2016-10-10 /pmc/articles/PMC5073486/ /pubmed/27843555 http://dx.doi.org/10.1136/bmjdrc-2016-000285 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Cardiovascular and Metabolic Risk
Nayak, Shivananda Bijoor
Ramnanansingh, Terry Gavaskar
Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure
title Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure
title_full Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure
title_fullStr Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure
title_full_unstemmed Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure
title_short Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure
title_sort evaluation of vitamin d relationship with type 2 diabetes and systolic blood pressure
topic Cardiovascular and Metabolic Risk
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073486/
https://www.ncbi.nlm.nih.gov/pubmed/27843555
http://dx.doi.org/10.1136/bmjdrc-2016-000285
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