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MicroRNAs interfere with DNA methylation in rheumatoid arthritis synovial fibroblasts

BACKGROUND: The DNA of rheumatoid arthritis synovial fibroblasts (RASF) is globally hypomethylated; this contributes to an aggressive behaviour. In an attempt to remethylate these cells, we supplemented with methyl donors. We investigated the possible interference of microRNAs (miRs). MATERIAL AND M...

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Detalles Bibliográficos
Autores principales:	Gaur, Niharika, Karouzakis, Emmanuel, Glück, Selene, Bagdonas, Edvardas, Jüngel, Astrid, Michel, Beat A, Gay, Renate E, Gay, Steffen, Frank-Bertoncelj, Mojca, Neidhart, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2016
Materias:	Rheumatoid Arthritis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073550/ https://www.ncbi.nlm.nih.gov/pubmed/27843576 http://dx.doi.org/10.1136/rmdopen-2016-000299

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