Effects of Rho1, a small GTPase on the production of recombinant glycoproteins in Saccharomyces cerevisiae

BACKGROUND: To humanize yeast N-glycosylation pathways, genes involved in yeast specific hyper-mannosylation must be disrupted followed by the introduction of genes catalyzing the synthesis, transport, and addition of human sugars. However, deletion of these genes, for instance, OCH1, which initiate...

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Detalles Bibliográficos
Autores principales: Xu, Sha, Zhang, Ge-Yuan, Zhang, Huijie, Kitajima, Toshihiko, Nakanishi, Hideki, Gao, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073930/
https://www.ncbi.nlm.nih.gov/pubmed/27769287
http://dx.doi.org/10.1186/s12934-016-0575-7

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