Low Frequency of Programmed Death Ligand 1 Expression in Pediatric Cancers

Programmed death 1 (PD‐1)/programmed death ligand 1 (PD‐L1) pathway blockade has become a promising therapeutic target in adult cancers. We evaluated PD‐L1 expression and tumor‐infiltrating CD8(+) T cells in formalin‐fixed, paraffin‐embedded tumor specimens from 53 untreated pediatric patients with...

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Autores principales: Aoki, Takahiro, Hino, Moeko, Koh, Katsuyoshi, Kyushiki, Masashi, Kishimoto, Hiroshi, Arakawa, Yuki, Hanada, Ryoji, Kawashima, Hiroshi, Kurihara, Jun, Shimojo, Naoki, Motohashi, Shinichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074238/
https://www.ncbi.nlm.nih.gov/pubmed/27135656
http://dx.doi.org/10.1002/pbc.26018
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author Aoki, Takahiro
Hino, Moeko
Koh, Katsuyoshi
Kyushiki, Masashi
Kishimoto, Hiroshi
Arakawa, Yuki
Hanada, Ryoji
Kawashima, Hiroshi
Kurihara, Jun
Shimojo, Naoki
Motohashi, Shinichiro
author_facet Aoki, Takahiro
Hino, Moeko
Koh, Katsuyoshi
Kyushiki, Masashi
Kishimoto, Hiroshi
Arakawa, Yuki
Hanada, Ryoji
Kawashima, Hiroshi
Kurihara, Jun
Shimojo, Naoki
Motohashi, Shinichiro
author_sort Aoki, Takahiro
collection PubMed
description Programmed death 1 (PD‐1)/programmed death ligand 1 (PD‐L1) pathway blockade has become a promising therapeutic target in adult cancers. We evaluated PD‐L1 expression and tumor‐infiltrating CD8(+) T cells in formalin‐fixed, paraffin‐embedded tumor specimens from 53 untreated pediatric patients with eight cancer types: neuroblastoma, extracranial malignant germ cell tumor, hepatoblastoma, germinoma, medulloblastoma, renal tumor, rhabdomyosarcoma, and atypical teratoid/rhabdoid tumor. One rhabdomyosarcoma with the shortest survival exhibited membranous PD‐L1 expression and germinoma contained abundant tumor‐infiltrating CD8(+) T cells and PD‐L1‐positive macrophages. The PD‐1/PD‐L1 pathway tended to be inactive in pediatric cancers.
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spelling pubmed-50742382016-11-04 Low Frequency of Programmed Death Ligand 1 Expression in Pediatric Cancers Aoki, Takahiro Hino, Moeko Koh, Katsuyoshi Kyushiki, Masashi Kishimoto, Hiroshi Arakawa, Yuki Hanada, Ryoji Kawashima, Hiroshi Kurihara, Jun Shimojo, Naoki Motohashi, Shinichiro Pediatr Blood Cancer Brief Reports Programmed death 1 (PD‐1)/programmed death ligand 1 (PD‐L1) pathway blockade has become a promising therapeutic target in adult cancers. We evaluated PD‐L1 expression and tumor‐infiltrating CD8(+) T cells in formalin‐fixed, paraffin‐embedded tumor specimens from 53 untreated pediatric patients with eight cancer types: neuroblastoma, extracranial malignant germ cell tumor, hepatoblastoma, germinoma, medulloblastoma, renal tumor, rhabdomyosarcoma, and atypical teratoid/rhabdoid tumor. One rhabdomyosarcoma with the shortest survival exhibited membranous PD‐L1 expression and germinoma contained abundant tumor‐infiltrating CD8(+) T cells and PD‐L1‐positive macrophages. The PD‐1/PD‐L1 pathway tended to be inactive in pediatric cancers. John Wiley and Sons Inc. 2016-05-02 2016-08 /pmc/articles/PMC5074238/ /pubmed/27135656 http://dx.doi.org/10.1002/pbc.26018 Text en © 2016 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/3.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Reports
Aoki, Takahiro
Hino, Moeko
Koh, Katsuyoshi
Kyushiki, Masashi
Kishimoto, Hiroshi
Arakawa, Yuki
Hanada, Ryoji
Kawashima, Hiroshi
Kurihara, Jun
Shimojo, Naoki
Motohashi, Shinichiro
Low Frequency of Programmed Death Ligand 1 Expression in Pediatric Cancers
title Low Frequency of Programmed Death Ligand 1 Expression in Pediatric Cancers
title_full Low Frequency of Programmed Death Ligand 1 Expression in Pediatric Cancers
title_fullStr Low Frequency of Programmed Death Ligand 1 Expression in Pediatric Cancers
title_full_unstemmed Low Frequency of Programmed Death Ligand 1 Expression in Pediatric Cancers
title_short Low Frequency of Programmed Death Ligand 1 Expression in Pediatric Cancers
title_sort low frequency of programmed death ligand 1 expression in pediatric cancers
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074238/
https://www.ncbi.nlm.nih.gov/pubmed/27135656
http://dx.doi.org/10.1002/pbc.26018
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