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A backbone amide protecting group for overcoming difficult sequences and suppressing aspartimide formation

A backbone amide bond protecting group, 2‐hydroxy‐4‐methoxy‐5‐nitrobenzyl (Hmnb), improved the synthesis of aggregation and aspartimide‐prone peptides. Introduction of Hmnb is automated and carried out during peptide assembly by addition of 4‐methoxy‐5‐nitrosalicylaldehyde to the peptidyl‐resin and...

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Detalles Bibliográficos
Autores principales:	Abdel‐Aal, Abu‐Baker M., Papageorgiou, George, Raz, Richard, Quibell, Martin, Burlina, Fabienne, Offer, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Special Issue Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074248/ https://www.ncbi.nlm.nih.gov/pubmed/27086749 http://dx.doi.org/10.1002/psc.2877

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