Species‐specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins

How host–virus co‐evolutionary relationships manifest is one of the most intriguing issues in virology. To address this topic, the mammal–lentivirus relationship can be considered as an interplay of cellular and viral proteins, particularly apolipoprotein B mRNA editing enzyme catalytic polypeptide‐...

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Autores principales: Yoshikawa, Rokusuke, Nakano, Yusuke, Yamada, Eri, Izumi, Taisuke, Misawa, Naoko, Koyanagi, Yoshio, Sato, Kei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074269/
https://www.ncbi.nlm.nih.gov/pubmed/26935128
http://dx.doi.org/10.1111/1348-0421.12371
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author Yoshikawa, Rokusuke
Nakano, Yusuke
Yamada, Eri
Izumi, Taisuke
Misawa, Naoko
Koyanagi, Yoshio
Sato, Kei
author_facet Yoshikawa, Rokusuke
Nakano, Yusuke
Yamada, Eri
Izumi, Taisuke
Misawa, Naoko
Koyanagi, Yoshio
Sato, Kei
author_sort Yoshikawa, Rokusuke
collection PubMed
description How host–virus co‐evolutionary relationships manifest is one of the most intriguing issues in virology. To address this topic, the mammal–lentivirus relationship can be considered as an interplay of cellular and viral proteins, particularly apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like 3 (APOBEC3) and viral infectivity factor (Vif). APOBEC3s enzymatically restrict lentivirus replication, whereas Vif antagonizes the host anti‐viral action mediated by APOBEC3. In this study, the focus was on the interplay between feline APOBEC3 proteins and two feline immunodeficiency viruses in cats and pumas. To our knowledge, this study provides the first evidence of non‐primate lentiviral Vif being incapable of counteracting a natural host's anti‐viral activity mediated via APOBEC3 protein.
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spelling pubmed-50742692016-11-04 Species‐specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins Yoshikawa, Rokusuke Nakano, Yusuke Yamada, Eri Izumi, Taisuke Misawa, Naoko Koyanagi, Yoshio Sato, Kei Microbiol Immunol Notes How host–virus co‐evolutionary relationships manifest is one of the most intriguing issues in virology. To address this topic, the mammal–lentivirus relationship can be considered as an interplay of cellular and viral proteins, particularly apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like 3 (APOBEC3) and viral infectivity factor (Vif). APOBEC3s enzymatically restrict lentivirus replication, whereas Vif antagonizes the host anti‐viral action mediated by APOBEC3. In this study, the focus was on the interplay between feline APOBEC3 proteins and two feline immunodeficiency viruses in cats and pumas. To our knowledge, this study provides the first evidence of non‐primate lentiviral Vif being incapable of counteracting a natural host's anti‐viral activity mediated via APOBEC3 protein. John Wiley and Sons Inc. 2016-04-15 2016-04 /pmc/articles/PMC5074269/ /pubmed/26935128 http://dx.doi.org/10.1111/1348-0421.12371 Text en © 2016 The Authors. Microbiology and Immunology Published by The Societies and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Notes
Yoshikawa, Rokusuke
Nakano, Yusuke
Yamada, Eri
Izumi, Taisuke
Misawa, Naoko
Koyanagi, Yoshio
Sato, Kei
Species‐specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins
title Species‐specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins
title_full Species‐specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins
title_fullStr Species‐specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins
title_full_unstemmed Species‐specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins
title_short Species‐specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins
title_sort species‐specific differences in the ability of feline lentiviral vif to degrade feline apobec3 proteins
topic Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074269/
https://www.ncbi.nlm.nih.gov/pubmed/26935128
http://dx.doi.org/10.1111/1348-0421.12371
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