Recent advances in understanding the extracellular calcium-sensing receptor

The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca (2+) and a surfeit of other endogenous ligands into multiple intracellular signa...

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Detalles Bibliográficos
Autores principales: Colella, Matilde, Gerbino, Andrea, Hofer, Aldebaran M., Curci, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074356/
https://www.ncbi.nlm.nih.gov/pubmed/27803801
http://dx.doi.org/10.12688/f1000research.8963.1
Descripción
Sumario:The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca (2+) and a surfeit of other endogenous ligands into multiple intracellular signals, but how is this achieved? This review will focus on some of the exciting concepts in CaR signaling and pharmacology that have emerged in the last few years.

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