Recent advances in understanding the extracellular calcium-sensing receptor

The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca (2+) and a surfeit of other endogenous ligands into multiple intracellular signa...

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Detalles Bibliográficos
Autores principales: Colella, Matilde, Gerbino, Andrea, Hofer, Aldebaran M., Curci, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074356/
https://www.ncbi.nlm.nih.gov/pubmed/27803801
http://dx.doi.org/10.12688/f1000research.8963.1
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author Colella, Matilde
Gerbino, Andrea
Hofer, Aldebaran M.
Curci, Silvana
author_facet Colella, Matilde
Gerbino, Andrea
Hofer, Aldebaran M.
Curci, Silvana
author_sort Colella, Matilde
collection PubMed
description The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca (2+) and a surfeit of other endogenous ligands into multiple intracellular signals, but how is this achieved? This review will focus on some of the exciting concepts in CaR signaling and pharmacology that have emerged in the last few years.
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spelling pubmed-50743562016-10-31 Recent advances in understanding the extracellular calcium-sensing receptor Colella, Matilde Gerbino, Andrea Hofer, Aldebaran M. Curci, Silvana F1000Res Review The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca (2+) and a surfeit of other endogenous ligands into multiple intracellular signals, but how is this achieved? This review will focus on some of the exciting concepts in CaR signaling and pharmacology that have emerged in the last few years. F1000Research 2016-10-19 /pmc/articles/PMC5074356/ /pubmed/27803801 http://dx.doi.org/10.12688/f1000research.8963.1 Text en Copyright: © 2016 Colella M et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Colella, Matilde
Gerbino, Andrea
Hofer, Aldebaran M.
Curci, Silvana
Recent advances in understanding the extracellular calcium-sensing receptor
title Recent advances in understanding the extracellular calcium-sensing receptor
title_full Recent advances in understanding the extracellular calcium-sensing receptor
title_fullStr Recent advances in understanding the extracellular calcium-sensing receptor
title_full_unstemmed Recent advances in understanding the extracellular calcium-sensing receptor
title_short Recent advances in understanding the extracellular calcium-sensing receptor
title_sort recent advances in understanding the extracellular calcium-sensing receptor
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074356/
https://www.ncbi.nlm.nih.gov/pubmed/27803801
http://dx.doi.org/10.12688/f1000research.8963.1
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