Cargando…

Functional and Structural Characterization of Purine Nucleoside Phosphorylase from Kluyveromyces lactis and Its Potential Applications in Reducing Purine Content in Food

Consumption of foods and beverages with high purine content increases the risk of hyperuricemia, which causes gout and can lead to cardiovascular, renal, and other metabolic disorders. As patients often find dietary restrictions challenging, enzymatically lowering purine content in popular foods and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mahor, Durga, Priyanka, Anu, Prasad, Gandham S, Thakur, Krishan Gopal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074518/ https://www.ncbi.nlm.nih.gov/pubmed/27768715 http://dx.doi.org/10.1371/journal.pone.0164279

Ejemplares similares

Biochemical Characterization of Kluyveromyces lactis Adenine Deaminase and Guanine Deaminase and Their Potential Application in Lowering Purine Content in Beer
por: Mahor, Durga, et al.
Publicado: (2018)

Purine nucleoside phosphorylase is associated with centrioles and basal bodies
Publicado: (1981)

Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases
por: Chaikuad, Apirat, et al.
Publicado: (2009)

Purine nucleoside phosphorylase deficiency in two unrelated Saudi patients
por: Alangari, Abdullah, et al.
Publicado: (2009)

Efficient Synthesis of Purine Nucleoside Analogs by a New Trimeric Purine Nucleoside Phosphorylase from Aneurinibacillus migulanus AM007
por: Liu, Gaofei, et al.
Publicado: (2019)

Structural Determinants of the 5′-Methylthioinosine Specificity of Plasmodium Purine Nucleoside Phosphorylase
por: Donaldson, Teraya M., et al.
Publicado: (2014)

Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells
por: Kropotov, Andrey, et al.
Publicado: (2022)

Synthesis of New 5′-Norcarbocyclic Aza/Deaza Purine Fleximers - Noncompetitive Inhibitors of E.coli Purine Nucleoside Phosphorylase
por: Khandazhinskaya, Anastasia, et al.
Publicado: (2022)

Purine nucleoside phosphorylase from Schistosoma mansoni in complex with ribose-1-phosphate
por: D’Muniz Pereira, Humberto, et al.
Publicado: (2011)

Purine nucleoside phosphorylase inhibitors - an immunotherapy with novel mechanism of action for the treatment of melanoma
por: Bantia, Shanta
Publicado: (2015)

Mitochondrial Basis for Immune Deficiency: Evidence from Purine Nucleoside Phosphorylase–Deficient Mice
por: Arpaia, Enrico, et al.
Publicado: (2000)

Metabolites of Purine Nucleoside Phosphorylase (NP) in Serum Have the Potential to Delineate Pancreatic Adenocarcinoma
por: Vareed, Shaiju K., et al.
Publicado: (2011)

Purine nucleoside phosphorylase inhibition ameliorates age-associated lower urinary tract dysfunctions
por: Birder, Lori A., et al.
Publicado: (2020)

Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors
por: Skácel, Jan, et al.
Publicado: (2023)

Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium
por: Narczyk, Marta, et al.
Publicado: (2022)

Adenosine deaminase and purine nucleoside phosphorylase activities in peripheral lymphocytes from patients with solid tumours.
por: Russo, M., et al.
Publicado: (1981)

Insights into Phosphate Cooperativity and Influence of Substrate Modifications on Binding and Catalysis of Hexameric Purine Nucleoside Phosphorylases
por: de Giuseppe, Priscila O., et al.
Publicado: (2012)

Purine Nucleoside Phosphorylase Targeted by Annexin V to Breast Cancer Vasculature for Enzyme Prodrug Therapy
por: Krais, John J., et al.
Publicado: (2013)

The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning
por: Decherchi, Sergio, et al.
Publicado: (2015)

Tricyclic Nucleobase Analogs and Their Ribosides as Substrates and Inhibitors of Purine-Nucleoside Phosphorylases III. Aminopurine Derivatives
por: Stachelska-Wierzchowska, Alicja, et al.
Publicado: (2020)

The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans
por: Tecle, Eillen, et al.
Publicado: (2021)

The structure of His-tagged Geobacillus stearothermophilus purine nucleoside phosphorylase reveals a ‘spanner in the works’
por: Given, Fiona M., et al.
Publicado: (2022)

8-Aminoinosine and 8-Aminohypoxanthine Inhibit Purine Nucleoside Phosphorylase and Exert Diuretic and Natriuretic Activity
por: Jackson, Edwin K., et al.
Publicado: (2022)

Cloning, purification and characterisation of a recombinant purine nucleoside phosphorylase from Bacillus halodurans Alk36
por: Visser, Daniel F., et al.
Publicado: (2010)

Tri-Cyclic Nucleobase Analogs and Their Ribosides as Substrates of Purine-Nucleoside Phosphorylases. II Guanine and Isoguanine Derivatives
por: Stachelska-Wierzchowska, Alicja, et al.
Publicado: (2019)

Partial Purine Nucleoside Phosphorylase Deficiency Helps Determine Minimal Activity Required for Immune and Neurological Development
por: Grunebaum, Eyal, et al.
Publicado: (2020)

Early Diagnosis and Treatment of Purine Nucleoside Phosphorylase (PNP) Deficiency through TREC-Based Newborn Screening
por: Martín-Nalda, Andrea, et al.
Publicado: (2021)

Correction: The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans
por: Tecle, Eillen, et al.
Publicado: (2022)

8‐Aminoguanine Induces Diuresis, Natriuresis, and Glucosuria by Inhibiting Purine Nucleoside Phosphorylase and Reduces Potassium Excretion by Inhibiting Rac1
por: Jackson, Edwin K., et al.
Publicado: (2018)

Incorporation of extracellular 8-oxodG into DNA and RNA requires purine nucleoside phosphorylase in MCF-7 cells
por: Mundt, Janna M., et al.
Publicado: (2008)

Purine Nucleoside Phosphorylase mediated molecular chemotherapy and conventional chemotherapy: A tangible union against chemoresistant cancer
por: Singh, Preetinder P, et al.
Publicado: (2011)

In Vitro Immunomodulatory Activity of a Transition-State Analog Inhibitor of Human Purine Nucleoside Phosphorylase in Cutaneous Leishmaniasis
por: Carvalho, Natália Barbosa, et al.
Publicado: (2017)

Immunodeficiency, Motor Delay, and Hypouricemia Caused by a Novel Mutation of Purine Nucleoside Phosphorylase Gene in an Indian Infant
por: Shah, Nikit, et al.
Publicado: (2019)

Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis
por: Štefanić, Zoran, et al.
Publicado: (2018)

Antitumor effects of a dual-specific lentiviral vector carrying the Escherichia coli purine nucleoside phosphorylase gene
por: Wang, Xiaolong, et al.
Publicado: (2017)

A comprehensive method for determining cellular uptake of purine nucleoside phosphorylase and adenylosuccinate synthetase inhibitors by H. pylori
por: Wojtyś, Marta Ilona, et al.
Publicado: (2021)

Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity
por: Abt, Evan R., et al.
Publicado: (2022)

Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient‐derived xenografts
por: Rab, Regina, et al.
Publicado: (2022)

Purine nucleosides: endogenous neuroprotectants in hypoxic brain
por: Thauerer, Bettina, et al.
Publicado: (2012)

Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model
por: Cassera, María B., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_170sjr2js4n8epuea4kp0us4br