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Increased serum levels of macrophage migration inhibitory factor (MIF) in patients with microscopic polyangiitis
OBJECTIVE: To test the hypothesis that macrophage migration inhibitory factor (MIF) is involved in the disease activity of systemic vasculitis. METHODS: Patients with systemic vasculitis were divided into three groups based on the size of the affected vessels. Microscopic polyangiitis (MPA) was cons...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074713/ https://www.ncbi.nlm.nih.gov/pubmed/27789977 |
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author | Kanemitsu, Hirohito Matsunawa, Mizuho Wakabayashi, Kuninobu Sato, Michihito Takahashi, Ryo Odai, Tsuyoshi Isozaki, Takeo Yajima, Nobuyuki Miwa, Yusuke Kasama, Tsuyoshi |
author_facet | Kanemitsu, Hirohito Matsunawa, Mizuho Wakabayashi, Kuninobu Sato, Michihito Takahashi, Ryo Odai, Tsuyoshi Isozaki, Takeo Yajima, Nobuyuki Miwa, Yusuke Kasama, Tsuyoshi |
author_sort | Kanemitsu, Hirohito |
collection | PubMed |
description | OBJECTIVE: To test the hypothesis that macrophage migration inhibitory factor (MIF) is involved in the disease activity of systemic vasculitis. METHODS: Patients with systemic vasculitis were divided into three groups based on the size of the affected vessels. Microscopic polyangiitis (MPA) was considered as small vessel vasculitis (SVV), polyarteritis nodosa as medium-sized vessel vasculitis (MVV), and giant cell arteritis and Takayasu arteritis as large vessel vasculitis (LVV). Sera from patients with systemic vasculitis and healthy individuals were collected, and MIF levels were measured using an enzyme-linked immunosorbent assay. Disease activity of vasculitis was assessed using the Birmingham Vasculitis Activity Score (BVAS). RESULTS: Serum MIF levels were significantly higher in the vasculitis patients than in healthy individuals. Among the vasculitis patients, MIF levels were significantly higher in patients in the SVV group (median; 4161.7 pg/ml) than in the other groups (MVV; 1443.2 pg/ml and LVV; 1576.7 pg/ml). In patients with MPA, a positive correlation was observed between serum MIF levels and CRP levels and disease activity (BVAS). Notably, serum MIF levels were significantly diminished after clinical improvement. CONCLUSIONS: Our findings suggest that MIF may have an important role in small vessel vasculopathy and serve as a useful serologic marker of MPA disease activity. |
format | Online Article Text |
id | pubmed-5074713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-50747132016-10-27 Increased serum levels of macrophage migration inhibitory factor (MIF) in patients with microscopic polyangiitis Kanemitsu, Hirohito Matsunawa, Mizuho Wakabayashi, Kuninobu Sato, Michihito Takahashi, Ryo Odai, Tsuyoshi Isozaki, Takeo Yajima, Nobuyuki Miwa, Yusuke Kasama, Tsuyoshi Open Access Rheumatol Original Research OBJECTIVE: To test the hypothesis that macrophage migration inhibitory factor (MIF) is involved in the disease activity of systemic vasculitis. METHODS: Patients with systemic vasculitis were divided into three groups based on the size of the affected vessels. Microscopic polyangiitis (MPA) was considered as small vessel vasculitis (SVV), polyarteritis nodosa as medium-sized vessel vasculitis (MVV), and giant cell arteritis and Takayasu arteritis as large vessel vasculitis (LVV). Sera from patients with systemic vasculitis and healthy individuals were collected, and MIF levels were measured using an enzyme-linked immunosorbent assay. Disease activity of vasculitis was assessed using the Birmingham Vasculitis Activity Score (BVAS). RESULTS: Serum MIF levels were significantly higher in the vasculitis patients than in healthy individuals. Among the vasculitis patients, MIF levels were significantly higher in patients in the SVV group (median; 4161.7 pg/ml) than in the other groups (MVV; 1443.2 pg/ml and LVV; 1576.7 pg/ml). In patients with MPA, a positive correlation was observed between serum MIF levels and CRP levels and disease activity (BVAS). Notably, serum MIF levels were significantly diminished after clinical improvement. CONCLUSIONS: Our findings suggest that MIF may have an important role in small vessel vasculopathy and serve as a useful serologic marker of MPA disease activity. Dove Medical Press 2009-03-13 /pmc/articles/PMC5074713/ /pubmed/27789977 Text en © 2009 Kanemitsu et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Kanemitsu, Hirohito Matsunawa, Mizuho Wakabayashi, Kuninobu Sato, Michihito Takahashi, Ryo Odai, Tsuyoshi Isozaki, Takeo Yajima, Nobuyuki Miwa, Yusuke Kasama, Tsuyoshi Increased serum levels of macrophage migration inhibitory factor (MIF) in patients with microscopic polyangiitis |
title | Increased serum levels of macrophage migration inhibitory factor (MIF) in patients with microscopic polyangiitis |
title_full | Increased serum levels of macrophage migration inhibitory factor (MIF) in patients with microscopic polyangiitis |
title_fullStr | Increased serum levels of macrophage migration inhibitory factor (MIF) in patients with microscopic polyangiitis |
title_full_unstemmed | Increased serum levels of macrophage migration inhibitory factor (MIF) in patients with microscopic polyangiitis |
title_short | Increased serum levels of macrophage migration inhibitory factor (MIF) in patients with microscopic polyangiitis |
title_sort | increased serum levels of macrophage migration inhibitory factor (mif) in patients with microscopic polyangiitis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074713/ https://www.ncbi.nlm.nih.gov/pubmed/27789977 |
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