The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells

BACKGROUND: Embelin is a potent dual inhibitor of 5-lipoxigenase (5-LOX) and microsomal prostaglandin E2 synthase (mPGES)-1 that suppresses proliferation of human glioma cells and induces apoptosis by inhibiting XIAP and NF-κB signaling pathway. Synthetic structural modification yielded the derivati...

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Detalles Bibliográficos
Autores principales: Zappavigna, S., Scuotto, M., Cossu, A. M., Ingrosso, D., De Rosa, M., Schiraldi, C., Filosa, R., Caraglia, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075202/
https://www.ncbi.nlm.nih.gov/pubmed/27770821
http://dx.doi.org/10.1186/s13046-016-0440-x

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