Unexpected effects of different genetic backgrounds on identification of genomic rearrangements via whole-genome next generation sequencing

BACKGROUND: Whole genome next generation sequencing (NGS) is increasingly employed to detect genomic rearrangements in cancer genomes, especially in lymphoid malignancies. We recently established a unique mouse model by specifically deleting a key non-homologous end-joining DNA repair gene, Xrcc4, a...

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Detalles Bibliográficos
Autores principales: Chen, Zhangguo, Gowan, Katherine, Leach, Sonia M., Viboolsittiseri, Sawanee S., Mishra, Ameet K., Kadoishi, Tanya, Diener, Katrina, Gao, Bifeng, Jones, Kenneth, Wang, Jing H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075209/
https://www.ncbi.nlm.nih.gov/pubmed/27769169
http://dx.doi.org/10.1186/s12864-016-3153-9

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