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Antinociceptive effect of methanol extract of Celosia cristata Linn. in mice
BACKGROUND: Celosia cristata Linn. (Amaranthaceae) is used in traditional medicine for the treatment of headache, sores, ulcers, eye inflammations, skin eruption, painful menstruation and carpal tunnel syndrome. This study was performed to evaluate the antinociceptive activity of methanol extract of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075210/ https://www.ncbi.nlm.nih.gov/pubmed/27770773 http://dx.doi.org/10.1186/s12906-016-1393-5 |
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author | Islam, Shanta Shajib, Md Shafiullah Ahmed, Tajnin |
author_facet | Islam, Shanta Shajib, Md Shafiullah Ahmed, Tajnin |
author_sort | Islam, Shanta |
collection | PubMed |
description | BACKGROUND: Celosia cristata Linn. (Amaranthaceae) is used in traditional medicine for the treatment of headache, sores, ulcers, eye inflammations, skin eruption, painful menstruation and carpal tunnel syndrome. This study was performed to evaluate the antinociceptive activity of methanol extract of the whole plant of C. cristata (MECC). METHODS: The evaluation of the antinociceptive effect of MECC was performed using thermal (hot plate, tail immersion test) and chemical (acetic acid, formalin, and glutamate-induced nociception test) pain models in mice at four different doses (50, 100, 200, 400 mg/kg; p.o.). Involvement of opioid receptors mediated central antinociceptive mechanism of MECC was evaluated using naloxone. Furthermore, the association of ATP-sensitive K(+) channel and cGMP pathway were evaluated using glibenclamide and methylene blue respectively. RESULTS: Oral treatment of MECC produced significant, strong and dose-dependent central and peripheral antinociceptive effect in experimental pain models. MECC significantly increased the latency time of thermal threshold in both hot plate and tail immersion test. The inhibition of writhing syndrome by the extract in the acetic acid-induced writhing test was remarkable. MECC significantly reduced the formalin-induced neurogenic and inflammatory pain. In addition, the inhibition of glutamate-induced paw licking and edema by MECC was significant. The antinociceptive effect was significantly reversed by naloxone and glibenclamide, suggesting the association of opioid and ATP-sensitive K(+) channel system respectively. In addition, MECC also demonstrated the involvement of cGMP pathway in the antinociceptive action. CONCLUSION: The study suggests that C. cristata possess significant antinociceptive effect which is associated with both central and peripheral mechanisms and provides a rationale for its extensive use at different painful conditions in traditional medicine. |
format | Online Article Text |
id | pubmed-5075210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-50752102016-10-27 Antinociceptive effect of methanol extract of Celosia cristata Linn. in mice Islam, Shanta Shajib, Md Shafiullah Ahmed, Tajnin BMC Complement Altern Med Research Article BACKGROUND: Celosia cristata Linn. (Amaranthaceae) is used in traditional medicine for the treatment of headache, sores, ulcers, eye inflammations, skin eruption, painful menstruation and carpal tunnel syndrome. This study was performed to evaluate the antinociceptive activity of methanol extract of the whole plant of C. cristata (MECC). METHODS: The evaluation of the antinociceptive effect of MECC was performed using thermal (hot plate, tail immersion test) and chemical (acetic acid, formalin, and glutamate-induced nociception test) pain models in mice at four different doses (50, 100, 200, 400 mg/kg; p.o.). Involvement of opioid receptors mediated central antinociceptive mechanism of MECC was evaluated using naloxone. Furthermore, the association of ATP-sensitive K(+) channel and cGMP pathway were evaluated using glibenclamide and methylene blue respectively. RESULTS: Oral treatment of MECC produced significant, strong and dose-dependent central and peripheral antinociceptive effect in experimental pain models. MECC significantly increased the latency time of thermal threshold in both hot plate and tail immersion test. The inhibition of writhing syndrome by the extract in the acetic acid-induced writhing test was remarkable. MECC significantly reduced the formalin-induced neurogenic and inflammatory pain. In addition, the inhibition of glutamate-induced paw licking and edema by MECC was significant. The antinociceptive effect was significantly reversed by naloxone and glibenclamide, suggesting the association of opioid and ATP-sensitive K(+) channel system respectively. In addition, MECC also demonstrated the involvement of cGMP pathway in the antinociceptive action. CONCLUSION: The study suggests that C. cristata possess significant antinociceptive effect which is associated with both central and peripheral mechanisms and provides a rationale for its extensive use at different painful conditions in traditional medicine. BioMed Central 2016-10-22 /pmc/articles/PMC5075210/ /pubmed/27770773 http://dx.doi.org/10.1186/s12906-016-1393-5 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Islam, Shanta Shajib, Md Shafiullah Ahmed, Tajnin Antinociceptive effect of methanol extract of Celosia cristata Linn. in mice |
title | Antinociceptive effect of methanol extract of Celosia cristata Linn. in mice |
title_full | Antinociceptive effect of methanol extract of Celosia cristata Linn. in mice |
title_fullStr | Antinociceptive effect of methanol extract of Celosia cristata Linn. in mice |
title_full_unstemmed | Antinociceptive effect of methanol extract of Celosia cristata Linn. in mice |
title_short | Antinociceptive effect of methanol extract of Celosia cristata Linn. in mice |
title_sort | antinociceptive effect of methanol extract of celosia cristata linn. in mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075210/ https://www.ncbi.nlm.nih.gov/pubmed/27770773 http://dx.doi.org/10.1186/s12906-016-1393-5 |
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