Cargando…

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass spectrometry, we generated dynamic metabolome and proteome profiles of human primary naive T cells following activation. We discovered critical changes in the arginine metabolism that led to a drop in int...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geiger, Roger, Rieckmann, Jan C., Wolf, Tobias, Basso, Camilla, Feng, Yuehan, Fuhrer, Tobias, Kogadeeva, Maria, Picotti, Paola, Meissner, Felix, Mann, Matthias, Zamboni, Nicola, Sallusto, Federica, Lanzavecchia, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075284/ https://www.ncbi.nlm.nih.gov/pubmed/27745970 http://dx.doi.org/10.1016/j.cell.2016.09.031

Ejemplares similares

Dynamics in protein translation sustaining T cell preparedness
por: Wolf, Tobias, et al.
Publicado: (2020)

Human naive and memory CD4(+) T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells
por: Geiger, Rebekka, et al.
Publicado: (2009)

SUMOFLUX: A Generalized Method for Targeted (13)C Metabolic Flux Ratio Analysis
por: Kogadeeva, Maria, et al.
Publicado: (2016)

Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells
por: Ronchi, Francesca, et al.
Publicado: (2016)

Mobilizing Dendritic Cells for Tolerance, Priming, and Chronic Inflammation
por: Sallusto, Federica, et al.
Publicado: (1999)

The instructive role of dendritic cells on T-cell responses
por: Sallusto, Federica, et al.
Publicado: (2002)

Human B cell memory
por: Lanzavecchia, Antonio, et al.
Publicado: (2009)

Bifunctional Malic/Malolactic Enzyme Provides a Novel Mechanism for NADPH-Balancing in Bacillus subtilis
por: Hörl, Manuel, et al.
Publicado: (2021)

Co‐catabolism of arginine and succinate drives symbiotic nitrogen fixation
por: Flores‐Tinoco, Carlos Eduardo, et al.
Publicado: (2020)

Cytokine-driven Proliferation and Differentiation of Human Naive, Central Memory, and Effector Memory CD4(+) T Cells
por: Geginat, Jens, et al.
Publicado: (2001)

Human monoclonal antibodies by immortalization of memory B cells
por: Lanzavecchia, Antonio, et al.
Publicado: (2007)

Regulation of yeast central metabolism by enzyme phosphorylation
por: Oliveira, Ana Paula, et al.
Publicado: (2012)

Somatic mutations and affinity maturation are impaired by excessive numbers of T follicular helper cells and restored by Treg cells or memory T cells
por: Preite, Silvia, et al.
Publicado: (2015)

Genomewide landscape of gene–metabolome associations in Escherichia coli
por: Fuhrer, Tobias, et al.
Publicado: (2017)

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes
por: Sallusto, Federica, et al.
Publicado: (1998)

Deciphering and predicting CD4(+) T cell immunodominance of influenza virus hemagglutinin
por: Cassotta, Antonino, et al.
Publicado: (2020)

Chemokine Receptor Expression Identifies Pre–T Helper (Th)1, Pre–Th2, and Nonpolarized Cells among Human CD4(+) Central Memory T Cells
por: Rivino, Laura, et al.
Publicado: (2004)

Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity
por: Fendt, Sarah-Maria, et al.
Publicado: (2010)

Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ
por: Cappelletti, Valentina, et al.
Publicado: (2021)

A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression
por: Macagno, Annalisa, et al.
Publicado: (2006)

Temporal system-level organization of the switch from glycolytic to gluconeogenic operation in yeast
por: Zampar, Guillermo G, et al.
Publicado: (2013)

CD40L(+) CD4(+) memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming
por: Martín-Fontecha, Alfonso, et al.
Publicado: (2008)

Coexpression of CD25 and CD27 identifies FoxP3(+) regulatory T cells in inflamed synovia
por: Ruprecht, Claudia R., et al.
Publicado: (2005)

Regulation of Dendritic Cell Migration to the Draining Lymph Node: Impact on T Lymphocyte Traffic and Priming
por: Martín-Fontecha, Alfonso, et al.
Publicado: (2003)

Rational Engineering of a Human Anti-Dengue Antibody through Experimentally Validated Computational Docking
por: Simonelli, Luca, et al.
Publicado: (2013)

The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation
por: Muri, Jonathan, et al.
Publicado: (2018)

Genome-wide RNAi screen identifies novel players in human 60S subunit biogenesis including key enzymes of polyamine metabolism
por: Dörner, Kerstin, et al.
Publicado: (2022)

Integration of Metabolomics and Transcriptomics Reveals a Complex Diet of Mycobacterium tuberculosis during Early Macrophage Infection
por: Zimmermann, Michael, et al.
Publicado: (2017)

Antibodies Produced by CLL Phenotype B Cells in Patients With Myasthenia Gravis Are Not Directed Against Neuromuscular Endplates
por: Ingelfinger, Florian, et al.
Publicado: (2023)

Correction: Therapeutic Efficacy of Antibodies Lacking Fc. Receptor Binding against Lethal Dengue Virus Infection Is Due to Neutralizing Potency and Blocking of Enhancing Antibodies
por: Williams, Katherine L., et al.
Publicado: (2013)

Therapeutic Efficacy of Antibodies Lacking FcγR against Lethal Dengue Virus Infection Is Due to Neutralizing Potency and Blocking of Enhancing Antibodies
por: Williams, Katherine L., et al.
Publicado: (2013)

Clonal composition and persistence of antigen‐specific circulating T follicular helper cells
por: Hu, Mengyun, et al.
Publicado: (2022)

Metabolic landscape of the male mouse gut identifies different niches determined by microbial activities
por: Meier, Karin H. U., et al.
Publicado: (2023)

Structural basis of malaria RIFIN binding by LILRB1-containing antibodies
por: Chen, Yiwei, et al.
Publicado: (2021)

Phenotype and specificity of T cells in primary human cytomegalovirus infection during pregnancy: IL-7R(pos) long-term memory phenotype is associated with protection from vertical transmission
por: Mele, Federico, et al.
Publicado: (2017)

Global analysis of protein arginine methylation
por: Zhang, Fangrong, et al.
Publicado: (2021)

Fetal Human Cytomegalovirus Transmission Correlates with Delayed Maternal Antibodies to gH/gL/pUL128-130-131 Complex during Primary Infection
por: Lilleri, Daniele, et al.
Publicado: (2013)

Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis
por: Piccoli, Luca, et al.
Publicado: (2015)

Magnetite-Arginine Nanoparticles as a Multifunctional Biomedical Tool
por: Reichel, Victoria E., et al.
Publicado: (2020)

Antigenic Fingerprinting of H5N1 Avian Influenza Using Convalescent Sera and Monoclonal Antibodies Reveals Potential Vaccine and Diagnostic Targets
por: Khurana, Surender, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_khmma75l8kri67oa2du8u4f57d