Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia

An analysis of the impact of orphanhood at antiretroviral therapy (ART) initiation on HIV outcomes in Asia included 4300 children; 51% were male. At ART initiation, 1805 (42%) were non-orphans (median age: 3 years), 1437 (33%) were single orphans (6 years) and 1058 (25%) were double orphans (7 years...

Descripción completa

Detalles Bibliográficos
Autores principales: Huy, Bui Vu, Teeraananchai, Sirinya, Oanh, Le Ngoc, Tucker, John, Kurniati, Nia, Hansudewechakul, Rawiwan, Truong, Khanh Huu, Khol, Vohith, Nguyen, Lam Van, Chau Do, Viet, Lumbiganon, Pagakrong, Kongstan, Nantaka, Bunupuradah, Torsak, Sudjaritruk, Tavitiya, Kumarasamy, Nagalingeswaran, Yusoff, Nik Khairulddin Nik, Mohd Razali, Kamarul Azahar, Wati, Dewi Kumara, Fong, Moy Siew, Nallusamy, Revathy, Kariminia, Azar, Sohn, Annette H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mediscript Ltd 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075350/
https://www.ncbi.nlm.nih.gov/pubmed/27781105
Descripción
Sumario:An analysis of the impact of orphanhood at antiretroviral therapy (ART) initiation on HIV outcomes in Asia included 4300 children; 51% were male. At ART initiation, 1805 (42%) were non-orphans (median age: 3 years), 1437 (33%) were single orphans (6 years) and 1058 (25%) were double orphans (7 years). Ten-year post-ART survival was 93.4–95.2% across orphan categories. Clinic transfers were higher among single and double orphans than non-orphans (41% vs 11%, P<0.001). On multivariate analysis, children ≥3 years at ART initiation (hazard ratio 1.58 vs <3 years, 95% confidence interval: 1.11–2.24) were more likely to be lost to follow-up. Although post-ART mortality and retention did not differ by orphan status, orphans were at greater risk of starting ART at older ages, and with more severe immunosuppression and poorer growth.

Ejemplares similares