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Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia

An analysis of the impact of orphanhood at antiretroviral therapy (ART) initiation on HIV outcomes in Asia included 4300 children; 51% were male. At ART initiation, 1805 (42%) were non-orphans (median age: 3 years), 1437 (33%) were single orphans (6 years) and 1058 (25%) were double orphans (7 years...

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Autores principales: Huy, Bui Vu, Teeraananchai, Sirinya, Oanh, Le Ngoc, Tucker, John, Kurniati, Nia, Hansudewechakul, Rawiwan, Truong, Khanh Huu, Khol, Vohith, Nguyen, Lam Van, Chau Do, Viet, Lumbiganon, Pagakrong, Kongstan, Nantaka, Bunupuradah, Torsak, Sudjaritruk, Tavitiya, Kumarasamy, Nagalingeswaran, Yusoff, Nik Khairulddin Nik, Mohd Razali, Kamarul Azahar, Wati, Dewi Kumara, Fong, Moy Siew, Nallusamy, Revathy, Kariminia, Azar, Sohn, Annette H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mediscript Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075350/
https://www.ncbi.nlm.nih.gov/pubmed/27781105
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author Huy, Bui Vu
Teeraananchai, Sirinya
Oanh, Le Ngoc
Tucker, John
Kurniati, Nia
Hansudewechakul, Rawiwan
Truong, Khanh Huu
Khol, Vohith
Nguyen, Lam Van
Chau Do, Viet
Lumbiganon, Pagakrong
Kongstan, Nantaka
Bunupuradah, Torsak
Sudjaritruk, Tavitiya
Kumarasamy, Nagalingeswaran
Yusoff, Nik Khairulddin Nik
Mohd Razali, Kamarul Azahar
Wati, Dewi Kumara
Fong, Moy Siew
Nallusamy, Revathy
Kariminia, Azar
Sohn, Annette H
author_facet Huy, Bui Vu
Teeraananchai, Sirinya
Oanh, Le Ngoc
Tucker, John
Kurniati, Nia
Hansudewechakul, Rawiwan
Truong, Khanh Huu
Khol, Vohith
Nguyen, Lam Van
Chau Do, Viet
Lumbiganon, Pagakrong
Kongstan, Nantaka
Bunupuradah, Torsak
Sudjaritruk, Tavitiya
Kumarasamy, Nagalingeswaran
Yusoff, Nik Khairulddin Nik
Mohd Razali, Kamarul Azahar
Wati, Dewi Kumara
Fong, Moy Siew
Nallusamy, Revathy
Kariminia, Azar
Sohn, Annette H
author_sort Huy, Bui Vu
collection PubMed
description An analysis of the impact of orphanhood at antiretroviral therapy (ART) initiation on HIV outcomes in Asia included 4300 children; 51% were male. At ART initiation, 1805 (42%) were non-orphans (median age: 3 years), 1437 (33%) were single orphans (6 years) and 1058 (25%) were double orphans (7 years). Ten-year post-ART survival was 93.4–95.2% across orphan categories. Clinic transfers were higher among single and double orphans than non-orphans (41% vs 11%, P<0.001). On multivariate analysis, children ≥3 years at ART initiation (hazard ratio 1.58 vs <3 years, 95% confidence interval: 1.11–2.24) were more likely to be lost to follow-up. Although post-ART mortality and retention did not differ by orphan status, orphans were at greater risk of starting ART at older ages, and with more severe immunosuppression and poorer growth.
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spelling pubmed-50753502016-10-25 Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia Huy, Bui Vu Teeraananchai, Sirinya Oanh, Le Ngoc Tucker, John Kurniati, Nia Hansudewechakul, Rawiwan Truong, Khanh Huu Khol, Vohith Nguyen, Lam Van Chau Do, Viet Lumbiganon, Pagakrong Kongstan, Nantaka Bunupuradah, Torsak Sudjaritruk, Tavitiya Kumarasamy, Nagalingeswaran Yusoff, Nik Khairulddin Nik Mohd Razali, Kamarul Azahar Wati, Dewi Kumara Fong, Moy Siew Nallusamy, Revathy Kariminia, Azar Sohn, Annette H J Virus Erad Original Research An analysis of the impact of orphanhood at antiretroviral therapy (ART) initiation on HIV outcomes in Asia included 4300 children; 51% were male. At ART initiation, 1805 (42%) were non-orphans (median age: 3 years), 1437 (33%) were single orphans (6 years) and 1058 (25%) were double orphans (7 years). Ten-year post-ART survival was 93.4–95.2% across orphan categories. Clinic transfers were higher among single and double orphans than non-orphans (41% vs 11%, P<0.001). On multivariate analysis, children ≥3 years at ART initiation (hazard ratio 1.58 vs <3 years, 95% confidence interval: 1.11–2.24) were more likely to be lost to follow-up. Although post-ART mortality and retention did not differ by orphan status, orphans were at greater risk of starting ART at older ages, and with more severe immunosuppression and poorer growth. Mediscript Ltd 2016-10-05 /pmc/articles/PMC5075350/ /pubmed/27781105 Text en © 2016 The Authors. Journal of Virus Eradication published by Mediscript Ltd http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article published under the terms of a Creative Commons License.
spellingShingle Original Research
Huy, Bui Vu
Teeraananchai, Sirinya
Oanh, Le Ngoc
Tucker, John
Kurniati, Nia
Hansudewechakul, Rawiwan
Truong, Khanh Huu
Khol, Vohith
Nguyen, Lam Van
Chau Do, Viet
Lumbiganon, Pagakrong
Kongstan, Nantaka
Bunupuradah, Torsak
Sudjaritruk, Tavitiya
Kumarasamy, Nagalingeswaran
Yusoff, Nik Khairulddin Nik
Mohd Razali, Kamarul Azahar
Wati, Dewi Kumara
Fong, Moy Siew
Nallusamy, Revathy
Kariminia, Azar
Sohn, Annette H
Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia
title Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia
title_full Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia
title_fullStr Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia
title_full_unstemmed Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia
title_short Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia
title_sort impact of orphan status on hiv treatment outcomes and retention in care of children and adolescents in asia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075350/
https://www.ncbi.nlm.nih.gov/pubmed/27781105
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