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Spongionella Secondary Metabolites, Promising Modulators of Immune Response through CD147 Receptor Modulation
The modulation of the immune system can have multiple applications such as cancer treatment, and a wide type of processes involving inflammation where the potent chemotactic agent cyclophilin A (Cyp A) is implicated. The Porifera phylum, in which Spongionella is encompassed, is the main producer of...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075563/ https://www.ncbi.nlm.nih.gov/pubmed/27822214 http://dx.doi.org/10.3389/fimmu.2016.00452 |
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author | Sánchez, Jon Andoni Alfonso, Amparo Rodriguez, Ines Alonso, Eva Cifuentes, José Manuel Bermudez, Roberto Rateb, Mostafa E. Jaspars, Marcel Houssen, Wael E. Ebel, Rainer Tabudravu, Jioji Botana, Luís M. |
author_facet | Sánchez, Jon Andoni Alfonso, Amparo Rodriguez, Ines Alonso, Eva Cifuentes, José Manuel Bermudez, Roberto Rateb, Mostafa E. Jaspars, Marcel Houssen, Wael E. Ebel, Rainer Tabudravu, Jioji Botana, Luís M. |
author_sort | Sánchez, Jon Andoni |
collection | PubMed |
description | The modulation of the immune system can have multiple applications such as cancer treatment, and a wide type of processes involving inflammation where the potent chemotactic agent cyclophilin A (Cyp A) is implicated. The Porifera phylum, in which Spongionella is encompassed, is the main producer of marine bioactive compounds. Four secondary metabolites obtained from Spongionella (Gracilin H, A, L, and Tetrahydroaplysulphurin-1) were described to hit Cyp A and to block the release of inflammation mediators. Based on these results, some role of Spongionella compounds on other steps of the signaling pathway mediated by this chemotactic agent can be hypothesized. In the present paper, we studied the effect of these four compounds on the surface membrane CD147 receptor expression, on the extracellular levels of Cyp A and on the ability to migrate of concanavalin (Con A)-activated T lymphocytes. Similar to a well-known immunosuppressive agent cyclosporine A (CsA), Gracilin H, A, L, and tetrahydroaplysulphurin-1 were able to reduce the CD147 membrane expression and to block the release of Cyp A to the medium. Besides, by using Cyp A as chemotactic agent, T cell migration was inhibited when cells were previously incubated with Gracilin A and Gracilin L. These positive results lead us to test the in vivo effect of Gracilin H and L in a mouse ear delayed hypersensitive reaction. Thus, both compounds efficiently reduce the ear swelling as well as the inflammatory cell infiltration. These results provide more evidences for their potential therapeutic application in immune-related diseases of Spongionella compounds. |
format | Online Article Text |
id | pubmed-5075563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50755632016-11-07 Spongionella Secondary Metabolites, Promising Modulators of Immune Response through CD147 Receptor Modulation Sánchez, Jon Andoni Alfonso, Amparo Rodriguez, Ines Alonso, Eva Cifuentes, José Manuel Bermudez, Roberto Rateb, Mostafa E. Jaspars, Marcel Houssen, Wael E. Ebel, Rainer Tabudravu, Jioji Botana, Luís M. Front Immunol Immunology The modulation of the immune system can have multiple applications such as cancer treatment, and a wide type of processes involving inflammation where the potent chemotactic agent cyclophilin A (Cyp A) is implicated. The Porifera phylum, in which Spongionella is encompassed, is the main producer of marine bioactive compounds. Four secondary metabolites obtained from Spongionella (Gracilin H, A, L, and Tetrahydroaplysulphurin-1) were described to hit Cyp A and to block the release of inflammation mediators. Based on these results, some role of Spongionella compounds on other steps of the signaling pathway mediated by this chemotactic agent can be hypothesized. In the present paper, we studied the effect of these four compounds on the surface membrane CD147 receptor expression, on the extracellular levels of Cyp A and on the ability to migrate of concanavalin (Con A)-activated T lymphocytes. Similar to a well-known immunosuppressive agent cyclosporine A (CsA), Gracilin H, A, L, and tetrahydroaplysulphurin-1 were able to reduce the CD147 membrane expression and to block the release of Cyp A to the medium. Besides, by using Cyp A as chemotactic agent, T cell migration was inhibited when cells were previously incubated with Gracilin A and Gracilin L. These positive results lead us to test the in vivo effect of Gracilin H and L in a mouse ear delayed hypersensitive reaction. Thus, both compounds efficiently reduce the ear swelling as well as the inflammatory cell infiltration. These results provide more evidences for their potential therapeutic application in immune-related diseases of Spongionella compounds. Frontiers Media S.A. 2016-10-24 /pmc/articles/PMC5075563/ /pubmed/27822214 http://dx.doi.org/10.3389/fimmu.2016.00452 Text en Copyright © 2016 Sánchez, Alfonso, Rodriguez, Alonso, Cifuentes, Bermudez, Rateb, Jaspars, Houssen, Ebel, Tabudravu and Botana. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Sánchez, Jon Andoni Alfonso, Amparo Rodriguez, Ines Alonso, Eva Cifuentes, José Manuel Bermudez, Roberto Rateb, Mostafa E. Jaspars, Marcel Houssen, Wael E. Ebel, Rainer Tabudravu, Jioji Botana, Luís M. Spongionella Secondary Metabolites, Promising Modulators of Immune Response through CD147 Receptor Modulation |
title | Spongionella Secondary Metabolites, Promising Modulators of Immune Response through CD147 Receptor Modulation |
title_full | Spongionella Secondary Metabolites, Promising Modulators of Immune Response through CD147 Receptor Modulation |
title_fullStr | Spongionella Secondary Metabolites, Promising Modulators of Immune Response through CD147 Receptor Modulation |
title_full_unstemmed | Spongionella Secondary Metabolites, Promising Modulators of Immune Response through CD147 Receptor Modulation |
title_short | Spongionella Secondary Metabolites, Promising Modulators of Immune Response through CD147 Receptor Modulation |
title_sort | spongionella secondary metabolites, promising modulators of immune response through cd147 receptor modulation |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075563/ https://www.ncbi.nlm.nih.gov/pubmed/27822214 http://dx.doi.org/10.3389/fimmu.2016.00452 |
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