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Use of Adipose-Derived Stem Cells to Support Topical Skin Adhesive for Wound Closure: A Preliminary Report from Animal In Vivo Study

The aim of this study was to determine the local and systemic effects of adipose-derived stem cells (ADSCs) as a component of topical skin adhesive in an animal artificial wound closure model. In presented study the cosmetic effects, histological analysis, mechanical properties, and cell migration h...

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Autores principales: Nowacki, Maciej, Pietkun, Katarzyna, Jundziłł, Arkadiusz, Kloskowski, Tomasz, Grzanka, Dariusz, Skopinska-Wisniewska, Joanna, Scibior, Kinga, Gagat, Maciej, Pokrywczyńska, Marta, Grzanka, Alina, Zegarski, Wojciech, Czajkowski, Rafał, Drewa, Tomasz, Zegarska, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075594/
https://www.ncbi.nlm.nih.gov/pubmed/27803921
http://dx.doi.org/10.1155/2016/2505601
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author Nowacki, Maciej
Pietkun, Katarzyna
Jundziłł, Arkadiusz
Kloskowski, Tomasz
Grzanka, Dariusz
Skopinska-Wisniewska, Joanna
Scibior, Kinga
Gagat, Maciej
Pokrywczyńska, Marta
Grzanka, Alina
Zegarski, Wojciech
Czajkowski, Rafał
Drewa, Tomasz
Zegarska, Barbara
author_facet Nowacki, Maciej
Pietkun, Katarzyna
Jundziłł, Arkadiusz
Kloskowski, Tomasz
Grzanka, Dariusz
Skopinska-Wisniewska, Joanna
Scibior, Kinga
Gagat, Maciej
Pokrywczyńska, Marta
Grzanka, Alina
Zegarski, Wojciech
Czajkowski, Rafał
Drewa, Tomasz
Zegarska, Barbara
author_sort Nowacki, Maciej
collection PubMed
description The aim of this study was to determine the local and systemic effects of adipose-derived stem cells (ADSCs) as a component of topical skin adhesive in an animal artificial wound closure model. In presented study the cosmetic effects, histological analysis, mechanical properties, and cell migration have been assessed to evaluate the usefulness of ADSCs as supporting factor for octyl blend cyanoacrylate adhesive. The total of 40 rats were used and divided into six groups. In the Study Group, ADSCs were administered by multipoint injection of the six surrounding intrawound areas with additional freely leaving procedure of the cells between the skin flaps just before applying adhesive to close the wound. Five control groups without using ADSCs, utilizing different types of standard wound closure, were created in order to check efficiency of experimental stem cell therapy. In our study, we proved that ADSCs could be used effectively also as a supportive tool in topical skin adhesive for wound closure. However we did not achieve any spectacular differences related to such aspects as better mechanical properties or special biological breakthroughs in wound healing properties. The use of stem cells, especially ADSCs for wound closure can provide an inspiring development in plastic and dermatologic surgery.
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spelling pubmed-50755942016-11-01 Use of Adipose-Derived Stem Cells to Support Topical Skin Adhesive for Wound Closure: A Preliminary Report from Animal In Vivo Study Nowacki, Maciej Pietkun, Katarzyna Jundziłł, Arkadiusz Kloskowski, Tomasz Grzanka, Dariusz Skopinska-Wisniewska, Joanna Scibior, Kinga Gagat, Maciej Pokrywczyńska, Marta Grzanka, Alina Zegarski, Wojciech Czajkowski, Rafał Drewa, Tomasz Zegarska, Barbara Biomed Res Int Research Article The aim of this study was to determine the local and systemic effects of adipose-derived stem cells (ADSCs) as a component of topical skin adhesive in an animal artificial wound closure model. In presented study the cosmetic effects, histological analysis, mechanical properties, and cell migration have been assessed to evaluate the usefulness of ADSCs as supporting factor for octyl blend cyanoacrylate adhesive. The total of 40 rats were used and divided into six groups. In the Study Group, ADSCs were administered by multipoint injection of the six surrounding intrawound areas with additional freely leaving procedure of the cells between the skin flaps just before applying adhesive to close the wound. Five control groups without using ADSCs, utilizing different types of standard wound closure, were created in order to check efficiency of experimental stem cell therapy. In our study, we proved that ADSCs could be used effectively also as a supportive tool in topical skin adhesive for wound closure. However we did not achieve any spectacular differences related to such aspects as better mechanical properties or special biological breakthroughs in wound healing properties. The use of stem cells, especially ADSCs for wound closure can provide an inspiring development in plastic and dermatologic surgery. Hindawi Publishing Corporation 2016 2016-10-10 /pmc/articles/PMC5075594/ /pubmed/27803921 http://dx.doi.org/10.1155/2016/2505601 Text en Copyright © 2016 Maciej Nowacki et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nowacki, Maciej
Pietkun, Katarzyna
Jundziłł, Arkadiusz
Kloskowski, Tomasz
Grzanka, Dariusz
Skopinska-Wisniewska, Joanna
Scibior, Kinga
Gagat, Maciej
Pokrywczyńska, Marta
Grzanka, Alina
Zegarski, Wojciech
Czajkowski, Rafał
Drewa, Tomasz
Zegarska, Barbara
Use of Adipose-Derived Stem Cells to Support Topical Skin Adhesive for Wound Closure: A Preliminary Report from Animal In Vivo Study
title Use of Adipose-Derived Stem Cells to Support Topical Skin Adhesive for Wound Closure: A Preliminary Report from Animal In Vivo Study
title_full Use of Adipose-Derived Stem Cells to Support Topical Skin Adhesive for Wound Closure: A Preliminary Report from Animal In Vivo Study
title_fullStr Use of Adipose-Derived Stem Cells to Support Topical Skin Adhesive for Wound Closure: A Preliminary Report from Animal In Vivo Study
title_full_unstemmed Use of Adipose-Derived Stem Cells to Support Topical Skin Adhesive for Wound Closure: A Preliminary Report from Animal In Vivo Study
title_short Use of Adipose-Derived Stem Cells to Support Topical Skin Adhesive for Wound Closure: A Preliminary Report from Animal In Vivo Study
title_sort use of adipose-derived stem cells to support topical skin adhesive for wound closure: a preliminary report from animal in vivo study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075594/
https://www.ncbi.nlm.nih.gov/pubmed/27803921
http://dx.doi.org/10.1155/2016/2505601
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