Salacia Extract Improves Postprandial Glucose and Insulin Response: A Randomized Double-Blind, Placebo Controlled, Crossover Study in Healthy Volunteers

Thirty-five healthy subjects were randomly assigned to different doses of Salacia chinensis extract (200 mg, 300 mg, and 500 mg SCE) capsules and compared with placebo. It is a placebo controlled randomized crossover design study. Subjects were given oral sucrose solution along with capsules and pla...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeykodi, Shankaranarayanan, Deshpande, Jayant, Juturu, Vijaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075619/
https://www.ncbi.nlm.nih.gov/pubmed/27803937
http://dx.doi.org/10.1155/2016/7971831
_version_ 1782461897831874560
author Jeykodi, Shankaranarayanan
Deshpande, Jayant
Juturu, Vijaya
author_facet Jeykodi, Shankaranarayanan
Deshpande, Jayant
Juturu, Vijaya
author_sort Jeykodi, Shankaranarayanan
collection PubMed
description Thirty-five healthy subjects were randomly assigned to different doses of Salacia chinensis extract (200 mg, 300 mg, and 500 mg SCE) capsules and compared with placebo. It is a placebo controlled randomized crossover design study. Subjects were given oral sucrose solution along with capsules and plasma glucose and insulin responses were analyzed. Blood samples were collected at 0, 30, 60, 90, 120, and 180 minutes after administration. AUC insulin significantly lowered after ingestion of SCE. No significant adverse events were observed. Reducing glucose and insulin is very important in reducing postprandial hyperglycemia.
format Online
Article
Text
id pubmed-5075619
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-50756192016-11-01 Salacia Extract Improves Postprandial Glucose and Insulin Response: A Randomized Double-Blind, Placebo Controlled, Crossover Study in Healthy Volunteers Jeykodi, Shankaranarayanan Deshpande, Jayant Juturu, Vijaya J Diabetes Res Clinical Study Thirty-five healthy subjects were randomly assigned to different doses of Salacia chinensis extract (200 mg, 300 mg, and 500 mg SCE) capsules and compared with placebo. It is a placebo controlled randomized crossover design study. Subjects were given oral sucrose solution along with capsules and plasma glucose and insulin responses were analyzed. Blood samples were collected at 0, 30, 60, 90, 120, and 180 minutes after administration. AUC insulin significantly lowered after ingestion of SCE. No significant adverse events were observed. Reducing glucose and insulin is very important in reducing postprandial hyperglycemia. Hindawi Publishing Corporation 2016 2016-10-10 /pmc/articles/PMC5075619/ /pubmed/27803937 http://dx.doi.org/10.1155/2016/7971831 Text en Copyright © 2016 Shankaranarayanan Jeykodi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Jeykodi, Shankaranarayanan
Deshpande, Jayant
Juturu, Vijaya
Salacia Extract Improves Postprandial Glucose and Insulin Response: A Randomized Double-Blind, Placebo Controlled, Crossover Study in Healthy Volunteers
title Salacia Extract Improves Postprandial Glucose and Insulin Response: A Randomized Double-Blind, Placebo Controlled, Crossover Study in Healthy Volunteers
title_full Salacia Extract Improves Postprandial Glucose and Insulin Response: A Randomized Double-Blind, Placebo Controlled, Crossover Study in Healthy Volunteers
title_fullStr Salacia Extract Improves Postprandial Glucose and Insulin Response: A Randomized Double-Blind, Placebo Controlled, Crossover Study in Healthy Volunteers
title_full_unstemmed Salacia Extract Improves Postprandial Glucose and Insulin Response: A Randomized Double-Blind, Placebo Controlled, Crossover Study in Healthy Volunteers
title_short Salacia Extract Improves Postprandial Glucose and Insulin Response: A Randomized Double-Blind, Placebo Controlled, Crossover Study in Healthy Volunteers
title_sort salacia extract improves postprandial glucose and insulin response: a randomized double-blind, placebo controlled, crossover study in healthy volunteers
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075619/
https://www.ncbi.nlm.nih.gov/pubmed/27803937
http://dx.doi.org/10.1155/2016/7971831
work_keys_str_mv AT jeykodishankaranarayanan salaciaextractimprovespostprandialglucoseandinsulinresponsearandomizeddoubleblindplacebocontrolledcrossoverstudyinhealthyvolunteers
AT deshpandejayant salaciaextractimprovespostprandialglucoseandinsulinresponsearandomizeddoubleblindplacebocontrolledcrossoverstudyinhealthyvolunteers
AT juturuvijaya salaciaextractimprovespostprandialglucoseandinsulinresponsearandomizeddoubleblindplacebocontrolledcrossoverstudyinhealthyvolunteers

Ejemplares similares