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Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions?

Citrate dialysate has been developed for few years to replace acetate and HCl concentrates. In Online Postdilution Hemodiafiltration (OL-POST-HDF), several issues are remaining concerning the possibility of stopping anticoagulation during sessions and the side effects of citrate solutions on calcium...

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Autores principales: Dolley-Hitze, Thibault, Oger, Emmanuel, Hamel, Didier, Lombart, Marie-Laure, Hermès, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075624/
https://www.ncbi.nlm.nih.gov/pubmed/27803814
http://dx.doi.org/10.1155/2016/9185413
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author Dolley-Hitze, Thibault
Oger, Emmanuel
Hamel, Didier
Lombart, Marie-Laure
Hermès, Isabelle
author_facet Dolley-Hitze, Thibault
Oger, Emmanuel
Hamel, Didier
Lombart, Marie-Laure
Hermès, Isabelle
author_sort Dolley-Hitze, Thibault
collection PubMed
description Citrate dialysate has been developed for few years to replace acetate and HCl concentrates. In Online Postdilution Hemodiafiltration (OL-POST-HDF), several issues are remaining concerning the possibility of stopping anticoagulation during sessions and the side effects of citrate solutions on calcium metabolism. This 1-year monocentric retrospective study included all patients exposed to citrate in OL-POST-HDF with nadroparin decrease for more than one month. Clotting events, serum calcium, PTH, hemoglobin, CRP, depuration parameters, and treatments administrated were recorded for analysis. 27 patients experienced nadroparin decrease and 5 did not receive nadroparin at the end of the study. Nadroparin decrease and withdrawal were both associated with more clotting events whereas the use of vitamin K antagonists was protective. No significant metabolic side effects were observed. Citrate dialysate does not allow anticoagulation discontinuation or decrease but has no significant side effects on mineral bone metabolism or erythropoiesis.
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spelling pubmed-50756242016-11-01 Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions? Dolley-Hitze, Thibault Oger, Emmanuel Hamel, Didier Lombart, Marie-Laure Hermès, Isabelle Int J Nephrol Clinical Study Citrate dialysate has been developed for few years to replace acetate and HCl concentrates. In Online Postdilution Hemodiafiltration (OL-POST-HDF), several issues are remaining concerning the possibility of stopping anticoagulation during sessions and the side effects of citrate solutions on calcium metabolism. This 1-year monocentric retrospective study included all patients exposed to citrate in OL-POST-HDF with nadroparin decrease for more than one month. Clotting events, serum calcium, PTH, hemoglobin, CRP, depuration parameters, and treatments administrated were recorded for analysis. 27 patients experienced nadroparin decrease and 5 did not receive nadroparin at the end of the study. Nadroparin decrease and withdrawal were both associated with more clotting events whereas the use of vitamin K antagonists was protective. No significant metabolic side effects were observed. Citrate dialysate does not allow anticoagulation discontinuation or decrease but has no significant side effects on mineral bone metabolism or erythropoiesis. Hindawi Publishing Corporation 2016 2016-10-10 /pmc/articles/PMC5075624/ /pubmed/27803814 http://dx.doi.org/10.1155/2016/9185413 Text en Copyright © 2016 Thibault Dolley-Hitze et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Dolley-Hitze, Thibault
Oger, Emmanuel
Hamel, Didier
Lombart, Marie-Laure
Hermès, Isabelle
Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions?
title Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions?
title_full Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions?
title_fullStr Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions?
title_full_unstemmed Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions?
title_short Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions?
title_sort is anticoagulation discontinuation achievable with citrate dialysate during hdf sessions?
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075624/
https://www.ncbi.nlm.nih.gov/pubmed/27803814
http://dx.doi.org/10.1155/2016/9185413
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