Cargando…
Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions?
Citrate dialysate has been developed for few years to replace acetate and HCl concentrates. In Online Postdilution Hemodiafiltration (OL-POST-HDF), several issues are remaining concerning the possibility of stopping anticoagulation during sessions and the side effects of citrate solutions on calcium...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075624/ https://www.ncbi.nlm.nih.gov/pubmed/27803814 http://dx.doi.org/10.1155/2016/9185413 |
_version_ | 1782461899044028416 |
---|---|
author | Dolley-Hitze, Thibault Oger, Emmanuel Hamel, Didier Lombart, Marie-Laure Hermès, Isabelle |
author_facet | Dolley-Hitze, Thibault Oger, Emmanuel Hamel, Didier Lombart, Marie-Laure Hermès, Isabelle |
author_sort | Dolley-Hitze, Thibault |
collection | PubMed |
description | Citrate dialysate has been developed for few years to replace acetate and HCl concentrates. In Online Postdilution Hemodiafiltration (OL-POST-HDF), several issues are remaining concerning the possibility of stopping anticoagulation during sessions and the side effects of citrate solutions on calcium metabolism. This 1-year monocentric retrospective study included all patients exposed to citrate in OL-POST-HDF with nadroparin decrease for more than one month. Clotting events, serum calcium, PTH, hemoglobin, CRP, depuration parameters, and treatments administrated were recorded for analysis. 27 patients experienced nadroparin decrease and 5 did not receive nadroparin at the end of the study. Nadroparin decrease and withdrawal were both associated with more clotting events whereas the use of vitamin K antagonists was protective. No significant metabolic side effects were observed. Citrate dialysate does not allow anticoagulation discontinuation or decrease but has no significant side effects on mineral bone metabolism or erythropoiesis. |
format | Online Article Text |
id | pubmed-5075624 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-50756242016-11-01 Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions? Dolley-Hitze, Thibault Oger, Emmanuel Hamel, Didier Lombart, Marie-Laure Hermès, Isabelle Int J Nephrol Clinical Study Citrate dialysate has been developed for few years to replace acetate and HCl concentrates. In Online Postdilution Hemodiafiltration (OL-POST-HDF), several issues are remaining concerning the possibility of stopping anticoagulation during sessions and the side effects of citrate solutions on calcium metabolism. This 1-year monocentric retrospective study included all patients exposed to citrate in OL-POST-HDF with nadroparin decrease for more than one month. Clotting events, serum calcium, PTH, hemoglobin, CRP, depuration parameters, and treatments administrated were recorded for analysis. 27 patients experienced nadroparin decrease and 5 did not receive nadroparin at the end of the study. Nadroparin decrease and withdrawal were both associated with more clotting events whereas the use of vitamin K antagonists was protective. No significant metabolic side effects were observed. Citrate dialysate does not allow anticoagulation discontinuation or decrease but has no significant side effects on mineral bone metabolism or erythropoiesis. Hindawi Publishing Corporation 2016 2016-10-10 /pmc/articles/PMC5075624/ /pubmed/27803814 http://dx.doi.org/10.1155/2016/9185413 Text en Copyright © 2016 Thibault Dolley-Hitze et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Dolley-Hitze, Thibault Oger, Emmanuel Hamel, Didier Lombart, Marie-Laure Hermès, Isabelle Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions? |
title | Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions? |
title_full | Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions? |
title_fullStr | Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions? |
title_full_unstemmed | Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions? |
title_short | Is Anticoagulation Discontinuation Achievable with Citrate Dialysate during HDF Sessions? |
title_sort | is anticoagulation discontinuation achievable with citrate dialysate during hdf sessions? |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075624/ https://www.ncbi.nlm.nih.gov/pubmed/27803814 http://dx.doi.org/10.1155/2016/9185413 |
work_keys_str_mv | AT dolleyhitzethibault isanticoagulationdiscontinuationachievablewithcitratedialysateduringhdfsessions AT ogeremmanuel isanticoagulationdiscontinuationachievablewithcitratedialysateduringhdfsessions AT hameldidier isanticoagulationdiscontinuationachievablewithcitratedialysateduringhdfsessions AT lombartmarielaure isanticoagulationdiscontinuationachievablewithcitratedialysateduringhdfsessions AT hermesisabelle isanticoagulationdiscontinuationachievablewithcitratedialysateduringhdfsessions |