Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways

TRPM7 is a potential therapeutic target for treatment of prostate cancer. In this study, we investigated the effects of nonselective TRPM7 inhibitor carvacrol on cell proliferation, migration, and invasion of prostate cancer PC-3 and DU145 cells. Our results showed that carvacrol blocked TRPM7-like...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Yun, Wu, Jie-Ying, Lu, Min-Hua, Shi, Zhi, Na, Ning, Di, Jin-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075627/
https://www.ncbi.nlm.nih.gov/pubmed/27803760
http://dx.doi.org/10.1155/2016/1469693
_version_ 1782461899805294592
author Luo, Yun
Wu, Jie-Ying
Lu, Min-Hua
Shi, Zhi
Na, Ning
Di, Jin-Ming
author_facet Luo, Yun
Wu, Jie-Ying
Lu, Min-Hua
Shi, Zhi
Na, Ning
Di, Jin-Ming
author_sort Luo, Yun
collection PubMed
description TRPM7 is a potential therapeutic target for treatment of prostate cancer. In this study, we investigated the effects of nonselective TRPM7 inhibitor carvacrol on cell proliferation, migration, and invasion of prostate cancer PC-3 and DU145 cells. Our results showed that carvacrol blocked TRPM7-like currents in PC-3 and DU145 cells and reduced their proliferation, migration, and invasion. Moreover, carvacrol treatment significantly decreased MMP-2, p-Akt, and p-ERK1/2 protein expression and inhibited F-actin reorganization. Furthermore, consistently, TRPM7 knockdown reduced prostate cancer cell proliferation, migration, and invasion as well. Our study suggests that carvacrol may have therapeutic potential for the treatment of prostate cancer through its inhibition of TRPM7 channels and suppression of PI3K/Akt and MAPK signaling pathways.
format Online
Article
Text
id pubmed-5075627
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-50756272016-11-01 Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways Luo, Yun Wu, Jie-Ying Lu, Min-Hua Shi, Zhi Na, Ning Di, Jin-Ming Oxid Med Cell Longev Research Article TRPM7 is a potential therapeutic target for treatment of prostate cancer. In this study, we investigated the effects of nonselective TRPM7 inhibitor carvacrol on cell proliferation, migration, and invasion of prostate cancer PC-3 and DU145 cells. Our results showed that carvacrol blocked TRPM7-like currents in PC-3 and DU145 cells and reduced their proliferation, migration, and invasion. Moreover, carvacrol treatment significantly decreased MMP-2, p-Akt, and p-ERK1/2 protein expression and inhibited F-actin reorganization. Furthermore, consistently, TRPM7 knockdown reduced prostate cancer cell proliferation, migration, and invasion as well. Our study suggests that carvacrol may have therapeutic potential for the treatment of prostate cancer through its inhibition of TRPM7 channels and suppression of PI3K/Akt and MAPK signaling pathways. Hindawi Publishing Corporation 2016 2016-10-10 /pmc/articles/PMC5075627/ /pubmed/27803760 http://dx.doi.org/10.1155/2016/1469693 Text en Copyright © 2016 Yun Luo et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Luo, Yun
Wu, Jie-Ying
Lu, Min-Hua
Shi, Zhi
Na, Ning
Di, Jin-Ming
Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways
title Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways
title_full Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways
title_fullStr Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways
title_full_unstemmed Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways
title_short Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways
title_sort carvacrol alleviates prostate cancer cell proliferation, migration, and invasion through regulation of pi3k/akt and mapk signaling pathways
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075627/
https://www.ncbi.nlm.nih.gov/pubmed/27803760
http://dx.doi.org/10.1155/2016/1469693
work_keys_str_mv AT luoyun carvacrolalleviatesprostatecancercellproliferationmigrationandinvasionthroughregulationofpi3kaktandmapksignalingpathways
AT wujieying carvacrolalleviatesprostatecancercellproliferationmigrationandinvasionthroughregulationofpi3kaktandmapksignalingpathways
AT luminhua carvacrolalleviatesprostatecancercellproliferationmigrationandinvasionthroughregulationofpi3kaktandmapksignalingpathways
AT shizhi carvacrolalleviatesprostatecancercellproliferationmigrationandinvasionthroughregulationofpi3kaktandmapksignalingpathways
AT naning carvacrolalleviatesprostatecancercellproliferationmigrationandinvasionthroughregulationofpi3kaktandmapksignalingpathways
AT dijinming carvacrolalleviatesprostatecancercellproliferationmigrationandinvasionthroughregulationofpi3kaktandmapksignalingpathways

Ejemplares similares